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Searching for Hif1-α interacting proteins in renal cell carcinoma
(Springer para Federation of Spanish Oncology Sociesties (FESEO), 2012-08-28)
[Abstract] Introduction. Kidney tumours are frequently characterised by hypoxic conditions due to a local imbalance between oxygen (O2) supply and consumption. Hif1-α regulates angiogenesis, tumour growth, tumour progression, ...
Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway
(BioMed Central, 2012-09-01)
[Abstract]
Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
State of the art in silico tools for the study of signaling pathways in cancer
(MDPI, 2012-05-29)
[Abstract] In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning ...
Circulating miR-200c as a diagnostic and prognostic biomarker for gastric cancer
(BioMed Central, 2012-09-06)
[Abstract]
Background. MicroRNAs are aberrantly expressed and correlate with tumourigenesis and the progression of solid tumours. The miR-200 family determines the epithelial phenotype of cancer cells and regulates ...
Evaluation of the adenocarcinoma-associated gene AGR2 and the intestinal stem cell marker LGR5 as biomarkers in colorectal cancer
(MDPI, 2012-04-05)
[Abstract] We aim to estimate the diagnostic performances of anterior gradient homolog-2 (AGR2) and Leucine-rich repeat-containing-G-protein-coupled receptor 5 (LGR5) in peripheral blood (PB) as mRNA biomarkers in colorectal ...