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Genome Wide CRISPR/Cas9 Screen Identifies the Coagulation Factor IX (F9) as a Regulator of Senescence
(Nature, 2022-02-19)
[Abstract] During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression. In this context, CDK4/6 inhibitors induce ...
Therapy free of cells vs human mesenchymal stem cells from umbilical cord stroma to treat the inflammation in OA
(Springer, 2022-10-20)
[Abstract] Osteoarthritis (OA) is closely linked to the increase in the number of senescent cells in joint tissues, and the senescence-associated secretory phenotype (SASP) is implicated in cartilage degradation. In the ...
Action Mechanisms of Small Extracellular Vesicles in Inflammaging [Review]
(MDPI, 2022-04-06)
[Abstract] The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation ...