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Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report

Núñez, Lucía; Crespo-Leiro, María Generosa; Marrón Liñares, Grecia Manuela; Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel (Via Médica, 2016)

[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction ...

Performance of prognostic risk scores in chronic heart failure patients enrolled in the European Society of Cardiology Heart Failure long-term registry

Canepa, Marco; Fonseca, Candida; Chioncel, Ovidiu; Laroche, Cécile; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Mebazaa, Alexandre (Elsevier, 2018-06)

[Abstract] Objectives. This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background. ...

Adherence to the ESC heart failure treatment guidelines in Spain: ESC Heart Failure Long-term Registry

Crespo-Leiro, María Generosa; Segovia Cubero, Javier; González-Costello, José; Bayes-Genis, Antoni; López-Fernández, Silvia; Roig, Eulàlia; Sanz-Julve, Marisa; Fernández-Vivancos, Carla; Mora-Martín, Manuel de; García-Pinilla, José Manuel; Varela-Román, Alfonso; Almenar-Bonet, Luis; Lara-Padrón, Antonio; Fuente Galán, Luis de la; Delgado-Jiménez, Juan F. (Elsevier para Sociedad Española de Cardiología, 2015-05-21)

[Abstract] Introduction and objectives. To estimate the percentage of heart failure patients in Spain that received the European Society of Cardiology recommended treatments, and in those that did not, to determine the ...

Comprehensive in‐hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)

Harjola, Veli-Pekka; Parissis, John; Brunner-La Rocca, Hans-Peter; Celutkiené, Jelena; Chioncel, Ovidiu; Collins, Sean P.; De Backer, Daniel; Filippatos, Gerasimos S.; Gayat, Etienne; Hill, Loreena; Lainscak, Mitja; Lassus, Johan; Masip, Josep; Mebazaa, Alexandre; Miró, Óscar; Mortara, Andrea; Mueller, Christian; Mullens, Wilfried; Nieminen, Markku S.; Rudiger, Alain; Ruschitzka, Frank; Seferovic, Petar M.; Sionis, Alessandro; Vieillard-Baron, Antoine; Weinstein, Jean Marc; Boer, Rudolf de; Crespo-Leiro, María Generosa; Piepoli, Massimo; Riley, Jillian P. (Wiley, 2018)

[Abstract] This paper provides a practical clinical application of guideline recommendations relating to the inpatient monitoring of patients with acute heart failure, through the evaluation of various clinical, ...

Expression of epicardial adipose tissue thermogenic genes in patients with reduced and preserved ejection fraction heart failure

Pérez-Belmonte, Luis M.; Moreno-Santos, Inmaculada; Gómez-Doblas, Juan J.; García-Pinilla, José Manuel; Morcillo-Hidalgo, Luis; Garrido-Sánchez, Lourdes; Santiago-Fernández, Concepción; Crespo-Leiro, María Generosa; Carrasco-Chinchilla, Fernando; Sánchez-Fernández, Pedro L.; Teresa Galván, Eduardo de; Jiménez-Navarro, Manuel (Ivyspring, 2017-07-20)

[Abstract] Epicardial adipose tissue has been proposed to participate in the pathogenesis of heart failure. The aim of our study was to assess the expression of thermogenic genes (Uncoupling protein 1 (UCP1), peroxisome ...

European Society of Cardiology Heart Failure Long‐Term Registry (ESC‐HF‐LT): 1‐year follow‐up outcomes and differences across regions

Crespo-Leiro, María Generosa; Anker, Stefan; Maggioni, Aldo P.; Coats, Andrew J.; Filippatos, Gerasimos; Ruschitzka, Frank; Ferrari, Roberto; Piepoli, Massimo Francesco; Delgado-Jiménez, Juan F.; Metra, Marco; Fonseca, Candida; Hradec, Jaromir; Amir, Offer; Logeart, Damien; Dahlström, Ulf; Merkely, Bela; Drozdz, Jaroslaw; Goncalvesova, Eva; Hassanein, Mahmoud; Chioncel, Ovidiu; Lainscak, Mitja; Seferovic, Petar M.; Tousoulis, Dimitris; Kavoliunene, Ausra; Fruhwald, Friedrich; Fazlibegovic, Emir; Temizhan, Ahmet; Gatzov, Plamen; Erglis, Andrejs; Laroche, Cecile; Mebazaa, Alexandre (Wiley, 2016-06-20)

[Abstract] AIMS: The European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT-R) was set up with the aim of describing the clinical epidemiology and the 1-year outcomes of patients with heart failure (HF) ...

Effect of β-blockers on 1-year survival and hospitalizations in patients with heart failure and atrial fibrillation: results from ESC-HF pilot and ESC-HF long-term registry

Ozieranski, Krzysztof; Kaplon-Cieslicka, Agnieszka; Balsam, Pawel; Tyminska, Agata; Wancerz, Anna; Peller, Michal; Marchel, Michal; Crespo-Leiro, María Generosa; Maggioni, Aldo P.; Drozdz, Jaroslaw; Filipiak, Krzysztof J.; Opolski, Grzegorz (Medycyna Praktyczna, 2018-10-10)

[Abstract] Introduction The positive effect of β-blocker therapy in patients with heart failure (HF) and atrial fibrillation (AF) has been questioned. Objectives We aimed to assess the effect of β-blockers and heart rate ...

Body surface area as a prognostic marker in chronic heart failure patients: results from the Heart Failure Registry of the Heart Failure Association of the European Society of Cardiology

Zafrir, Barak; Salman, Nabeeh; Crespo-Leiro, María Generosa; Anker, Stefan; Coats, Andrew J.; Ferrari, Roberto; Filippatos, Gerasimos; Maggioni, Aldo P.; Mebazaa, Alexandre; Piepoli, Massimo Francesco; Ruschitzka, Frank; Paniagua-Martín, María J.; Segovia-Cubero, Javier; Laroche, Cecile; Amir, Offer (Wiley, 2016-07-18)

[Abstract] AIMS: The 'obesity paradox' is consistently observed in patients with heart failure (HF). We investigated the relationship of body surface area (BSA) to mortality and hospitalizations in patients with chronic ...

Epidemiology and one‐year outcomes in patients with chronic heart failure and preserved, mid‐range and reduced ejection fraction: an analysis of the ESC Heart Failure Long‐Term Registry

Chioncel, Ovidiu; Lainscak, Mitja; Seferovic, Petar M.; Anker, Stefan; Crespo-Leiro, María Generosa; Harjola, Veli-Pekka; Parissis, John; Laroche, Cecile; Piepoli, Massimo Francesco; Fonseca, Candida; Mebazaa, Alexandre; Lund, Lars H.; Ambrosio, Giuseppe A.; Coats, Andrew J.; Ferrari, Roberto; Ruschitzka, Frank; Maggioni, Aldo P.; Filippatos, Gerasimos (Wiley, 2017-04-06)

[Abstract] AIMS: The objectives of the present study were to describe epidemiology and outcomes in ambulatory heart failure (HF) patients stratified by left ventricular ejection fraction (LVEF) and to identify predictors ...

Anemia at hospital admission and its relation to outcomes in patients with heart failure (from the polish cohort of 2 European Society of Cardiology Heart Failure Registries)

Tyminska, Agata; Kaplon-Cieslicka, Agnieszka; Ozieranski, Krzysztof; Peller, Michal; Balsam, Pawel; Marchel, Michal; Crespo-Leiro, María Generosa; Maggioni, Aldo P.; Jankowska, Ewa A.; Drozdz, Jaroslaw; Filipiak, Krzysztof J.; Opolski, Grzegorz (Elsevier, 2017)

[Abstract] Anemia is a commonly observed co-morbidity in heart failure (HF). The aim of the study was to assess prevalence, risk factors for, and effect of anemia on short- and long-term outcomes in HF. The study included ...