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Analysis of variants in the HCN4 gene and in three single nucleotide polymorphisms of the CYP3A4 gene for association with ivabradine reduction in heart rate: a preliminary report

Núñez, Lucía; Crespo-Leiro, María Generosa; Marrón Liñares, Grecia Manuela; Suárez-Fuentetaja, Natalia; Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Grille Cancela, Zulaika; Muñiz, Javier; Vázquez-Rodríguez, José Manuel; Hermida-Prieto, Manuel (Via Médica, 2016)

[Abstract] Background: Ivabradine, a selective bradycardic drug, inhibits the If. In patients with heart failure (HF), ivabradine reduces the risk of rehospitalization and mortality. The average heart rate (HR) reduction ...

Performance of prognostic risk scores in chronic heart failure patients enrolled in the European Society of Cardiology Heart Failure long-term registry

Canepa, Marco; Fonseca, Candida; Chioncel, Ovidiu; Laroche, Cécile; Crespo-Leiro, María Generosa; Coats, Andrew J.S.; Mebazaa, Alexandre (Elsevier, 2018-06)

[Abstract] Objectives. This study compared the performance of major heart failure (HF) risk models in predicting mortality and examined their utilization using data from a contemporary multinational registry. Background. ...

A randomized clinical trial to determine the effect of angiotensin inhibitors reduction on creatinine clearance and haemoglobin in heart failure patients with chronic kidney disease and anaemia

Pita-Fernández, Salvador; Chouciño Fernández, Teresa; Juega-Puig, J.; Seoane-Pillado, Teresa; López-Calviño, Beatriz; Pértega-Díaz, Sonia; Pedreira, José D.; Gil-Guillén, V. (Wiley, 2014-07-16)

[Abstract] Background. Chronic kidney disease is a common comorbidity in elderly patients with heart failure. Evidence supports the use of angiotensin inhibitors for patients with heart failure. However, there is little ...

Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro

Torrado, Mario; Iglesias Reinoso, Raquel; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (SAPE / Society for Experimental Biology and Medicine, 2010)

[Abstract] Brain natriuretic peptide/natriuretic peptide precursor B (NPPB) is one of the most studied genes in relation to heart failure (HF) conditions. However, it is still unclear as to whether alternative splicing ...

Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium

Torrado, Mario; Iglesias, Raquel; Nespereira, Beatriz; Centeno, Alberto; López, Eduardo; Mikhailov, Alexander T. (Elsevier, 2009-03-31)

[Abstract] The cardiac ankyrin repeat domain 1 protein (ANKRD1, also known as CARP) has been extensively characterized with regard to its proposed functions as a cardio-enriched transcriptional co-factor and stress-inducible ...

Usefulness of the INTERMACS scale for predicting outcomes after urgent heart transplantation

Barge-Caballero, Eduardo; Paniagua-Martín, María J.; Marzoa Rivas, Raquel; Campo-Pérez, Rosa; Rodríguez-Fernández, José Ángel; Pérez-Pérez, Alberto; García-Bueno, Lourdes; Blanco-Canosa, Paula; Grille Cancela, Zulaika; Solla-Buceta, Miguel; Juffé-Stein, Alberto; Herrera-Noreña, José M.; Cuenca, José J.; Muñiz, Javier; Castro-Beiras, Alfonso; Crespo-Leiro, María Generosa (Elsevier, 2011)

[Abstract] Introduction and objectives. Our aim was to assess the prognostic value of the INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) scale in patients undergoing urgent heart transplantation ...

Prevalence of heart failure in the spanish general population aged over 45 years. the PRICE study

Anguita, Manuel; Crespo-Leiro, María Generosa; Teresa Galván, Eduardo de; Jiménez-Navarro, Manuel; Alonso-Pulpón, Luis; Muñiz, Javier (Elsevier, 2009-01-15)

[Abstract] Introduction and objectives. Congestive heart failure is associated with substantial morbidity and mortality and both its incidence and prevalence are high. Nevertheless, comprehensive data on this condition in ...

Differences in outcome of heart failure with preserved or depressed systolic function in patients older than 70 years who receive beta blockers

Anguita, Manuel; Castillo, Juan C.; Ruiz, Martín; Castillo, Francisco; Jiménez-Navarro, Manuel; Crespo-Leiro, María Generosa; Alonso-Pulpón, Luis; Teresa Galván, Eduardo de; Castro-Beiras, Alfonso; Roig, Eulàlia; Artigas, Remei; Zapata, Antonio; López-de-Ullibarri, Ignacio; Muñiz, Javier (Elsevier, 2011-10-14)

[Abstract] Introduction and objectives. Most studies have shown that prognosis of heart failure with preserved systolic function is as poor as that of heart failure with depressed systolic function, although these results ...

Chronic anemia in heart transplant patients: prevalence, risk factors, and prognostic significance

Cursack, Guillermo C.; Crespo-Leiro, María Generosa; Paniagua-Martín, María J.; Muñiz, Javier; Naya, Carmen; Grille Cancela, Zulaika; Rodríguez-Fernández, José Ángel; Marzoa Rivas, Raquel; Barge-Caballero, Eduardo; Ríos, Ramón; Estévez, Francisco; Cuenca, José J.; Juffé-Stein, Alberto; Castro-Beiras, Alfonso (Elsevier, 2007)

[Abstract] Introduction and objectives. Data on chronic anemia following heart transplantation (HT) are scarce and contradictory. Our aims were to determine the prevalence of chronic anemia after HT, to identify predisposing ...

Uso de anticoagulación al alta hospitalaria en pacientes con insuficiencia cardíaca y fibrilación auricular

Mosquera Pérez, Ignacio; Muñiz, Javier; Freire Castroseiros, Evaristo; García Castelo, Alberto; Castro-Beiras, Alfonso (Elsevier, 2003)

[Resumen] Introducción y objetivos. Evaluar el grado de cumplimiento de las guías sobre uso de anticoagulación crónica en pacientes con insuficiencia cardíaca y fibrilación auricular. Pacientes y método. Se usó la base ...