Listar1. Investigación por tema "Gene therapy"
Mostrando ítems 1-6 de 6
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Controlled Release of rAAV Vectors from APMA-Functionalized Contact Lenses for Corneal Gene Therapy
(MDPI, 2020-04-09)[Abstract] As an alternative to eye drops and ocular injections for gene therapy, the aim of this work was to design for the first time hydrogel contact lenses that can act as platforms for the controlled delivery of ... -
Current trends in viral gene therapy for human orthopaedic regenerative medicine
(Springer, 2019-02-21)[Abstract] Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains ... -
Development of new non-viral systems for genetic modification of senescent cells
(Cell Press, 2023-03-20)[Abstract] Senescence is a process characterized by a prolonged irreversible cell-cycle arrest. The accumulation of senescent cells in tissues is related to aging and to the development of age-related diseases. Recently, ... -
Hydrogel-based localized nonviral gene delivery in regenerative medicine approaches: an overview
(MDPI, 2020-08-10)[Abstract] Hydrogel-based nonviral gene delivery constitutes a powerful strategy in various regenerative medicine scenarios, as those concerning the treatment of musculoskeletal, cardiovascular, or neural tissues disorders ... -
Scaffold-Mediated Gene Delivery for Osteochondral Repair
(MDPI, 2020-09-29)[Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
(WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...