Listar 1. Investigación por autor "Fernández-Puente, Patricia"

Mostrando ítems 1-10 de 10

    • A meta-analysis and a functional study support the influence of mtDNA variant m.16519C on the risk of rapid progression of knee osteoarthritis 

      Durán-Sotuela, Alejandro; Fernández-Moreno, Mercedes; Suárez-Ulloa, Victoria; Vázquez-García, Jorge; Relaño, Sara; Hermida-Gómez, Tamara; Balboa-Barreiro, Vanesa; Lourido-Salas, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Ruiz-Romero, Cristina; Fernández-Tajes, Juan; Vaamonde-García, Carlos; de Andrés, María C.; Oreiro, Natividad; Blanco García, Francisco J; Rego-Pérez, Ignacio (BMJ, 2023-04-06)
      [Abstract] Objectives: To identify mitochondrial DNA (mtDNA) genetic variants associated with the risk of rapid progression of knee osteoarthritis (OA) and to characterise their functional significance using a cellular ...

    • A novel procedure for protein extraction from formalin-fixed paraffin-embedded tissues 

      Rodríguez-Rigueiro, Teresa; Valladares-Ayerbes, Manuel; Haz, Mar; Blanco, Moisés; Aparicio Gallego, Guadalupe; Fernández-Puente, Patricia; Blanco García, Francisco J; Lorenzo-Patiño, María J.; Antón-Aparicio, Luis M.; Figueroa, Angélica (Wiley, 2011-05-18)
      [Abstract] Most of the archived pathological specimens in hospitals are kept as formalin-fixed paraffin-embedded tissues (FFPE) for long-term preservation. Up to now, these samples are only used for immunohistochemistry ...

    • A pharmacoproteomic study confirms the synergistic effect of chondroitin sulfate and glucosamine 

      Calamia, Valentina; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Fernández-Costa, Carolina; Montell, Eulalia; Vergés, Josep; Ruiz-Romero, Cristina; Blanco García, Francisco J (Nature, 2014-06-10)
      [Abstract] Osteoarthritis (OA) is the most common age-related rheumatic disease. Chondrocytes play a primary role in mediating cartilage destruction and extracellular matrix (ECM) breakdown, which are main features of the ...

    • An atlas of the knee joint proteins and their role in osteoarthritis defined by literature mining 

      Paz-González, Rocío; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Quaranta, Patricia; Picchi, Florencia; Blanco García, Francico J; Ruiz-Romero, Cristina (Elsevier, 2023-08)
      [Abstract] Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common ...

    • Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers 

      Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
      [Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...

    • Association of the serological status of rheumatoid arthritis patients with two circulating protein biomarkers: a useful tool for precision medicine strategies 

      Ruiz-Romero, Cristina; Fernández-Puente, Patricia; González, Lucía; Illiano, Anna; Lourido, Lucía; Paz, Rocío; Quaranta, Patricia; Pérez-Pampín, Eva; González, Antonio; Blanco García, Francisco J; Calamia, Valentina (Frontiers, 2022-10-28)
      [Abstract] Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joints and presence of systemic autoantibodies, with a great clinical and molecular heterogeneity. Rheumatoid Factor ...

    • Integrative Metabolic Pathway Analysis Reveals Novel Therapeutic Targets in Osteoarthritis 

      Rocha Loureda, Beatriz; Cillero-Pastor, B.; Eijkel, Gert; Calamia, Valentina; Fernández-Puente, Patricia; Paine, Martin R.L.; Ruiz-Romero, Cristina; Heeren, Ron M.A.; Blanco García, Francisco J (American Society for Biochemistry and Molecular Biology (ASBMB), 2020-01-24)
      [Abstract] In osteoarthritis (OA), impairment of cartilage regeneration can be related to a defective chondrogenic differentiation of mesenchymal stromal cells (MSCs). Therefore, understanding the proteomic- and ...

    • iTRAQ-Based Analysis of Progerin Expression Reveals Mitochondrial Dysfunction, Reactive Oxygen Species Accumulation and Altered Proteostasis 

      Mateos, Jesús; Landeira-Abia, Arancha; Fafián Labora, Juan Antonio; Fernández-Pernas, Pablo; Lesende-Rodríguez, Iván; Fernández-Puente, Patricia; Fernández-Moreno, Mercedes; Delmiro, Aitor; Martín, Miguel A.; Blanco García, Francisco J; Arufe, M.C. (BioMed Central, 2015-06-12)
      [Abstract] Introduction. Nuclear accumulation of a mutant form of the nuclear protein Lamin-A, called Progerin (PG) or Lamin AΔ50, occurs in Hutchinson-Gilford Progeria Syndrome (HGPS) or Progeria, an accelerated aging ...

    • Predictive modeling of therapeutic response to chondroitin sulfate/glucosamine hydrochloride in knee osteoarthritis 

      Blanco García, Francisco J; Camacho Encina, María; González-Rodríguez, Lucía; Rego-Pérez, Ignacio; Mateos, Jesús; Fernández-Puente, Patricia; Lourido Salas, Lucía María; Rocha Loureda, Beatriz; Picchi, Florencia; Silva-Díaz, María T.; Herrero, Marta; Martínez, Helena; Verges, Josep; Ruiz-Romero, Cristina; Calamia, Valentina (Sage, 2019-08-24)
      [Abstract] Background: In the present study, we explored potential protein biomarkers useful to predict the therapeutic response of knee osteoarthritis (KOA) patients treated with pharmaceutical grade Chondroitin ...

    • Prognostic model to predict the incidence of radiographic knee osteoarthritis 

      Paz-González, Rocío; Balboa-Barreiro, Vanesa; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Oreiro, Natividad; Ruiz-Romero, Cristina; Blanco García, Francico J (BMJ, 2024-01-05)
      [Abstract] Objective: Early diagnosis of knee osteoarthritis (KOA) in asymptomatic stages is essential for the timely management of patients using preventative strategies. We develop and validate a prognostic model useful ...