Listar 1. Investigación por autor "Rodríguez, Jaime"
Mostrando ítems 21-34 de 34
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Marine Organisms from the Yucatan Peninsula (Mexico) as a Potential Natural Source of Antibacterial Compounds
Pech-Puch, Dawrin; Pérez Povedano, Mar Anabel; Gómez, Patricia; Martínez-Guitián, Marta; Lasarte-Monterrubio, Cristina; Vázquez-Ucha, Juan Carlos; Novoa Olmedo, María Lourdes; Guillén-Hernández, Sergio; Villegas-Hernández, Harold; Bou, Germán; Rodríguez, Jaime; Beceiro, Alejandro; Jiménez, Carlos (MDPI, 2020-07-18)[Abstract] A total of 51 sponges (Porifera) and 13 ascidians (Chordata) were collected on the coast of the Yucatan Peninsula (Mexico) and extracted with organic solvents. The resulting extracts were screened for antibacterial ... -
Multistage Detection of Tetrodotoxin Traces in Diodon hystrix Collected in El Salvador
Fuentes-Monteverde, Juan Carlos; Núñez, Marvin J.; Amaya, Oscar; Martínez, Morena L.; Rodríguez, Jaime; Jiménez, Carlos (MDPI, 2023-06-25)[Abstract] This study describes a multistage methodology to detect minute amounts of tetrodotoxin in fishes, a plan that may be broadened to include other marine organisms. This methodology was applied to porcupinefish ... -
Natural Products from Antarctic Colonial Ascidians of the Genera Aplidium and Synoicum: Variability and Defensive Role
Núñez-Pons, Laura; Carbone, Marianna; Vázquez, Jennifer; Rodríguez, Jaime; Nieto, Rosa M.; Varela, María Mercedes; Gavagnin, Margherita; Ávila, Conxita (Molecular Diversity Preservation International, 2012)Ascidians have developed multiple defensive strategies mostly related to physical, nutritional or chemical properties of the tunic. One of such is chemical defense based on secondary metabolites. We analyzed a series of ... -
Preparation of Functionalized Magnetic Nanoparticles Conjugated with Feroxamine and Their Evaluation for Pathogen Detection
Martínez Matamoros, Diana; Castro-García, Socorro; Balado, Miguel; Matamoros Veloza, Adriana; Camargo-Valero, Miller Alonso; Óscar, Céspedes; Rodríguez, Jaime; Lemos, Manuel L.; Jiménez, Carlos (Royal Society of Chemistry, 2019-05-01)[Abstract] This work reports the preparation of a conjugate between amino-functionalized silica magnetite and the siderophore feroxamine. The morphology and properties of the conjugate and intermediate magnetic nanoparticles ... -
Relative Configuration of Micrograms of Natural Compounds Using Proton Residual Chemical Shift Anisotropy
Nath, Nilamoni; Fuentes-Monteverde, Juan Carlos; Pech-Puch, Dawrin; Rodríguez, Jaime; Jiménez, Carlos; Noll, Markus; Kreiter, Alexander; Reggelin, Michael; Navarro-Vázquez, Armando; Griesinger, Christian (Nature, 2020-09-01)[Abstract] 3D molecular structure determination is a challenge for organic compounds or natural products available in minute amounts. Proton/proton and proton/carbon correlations yield the constitution. J couplings and ... -
Selective Detection of Aeromonas Spp. By a Fluorescent Probe Based on the Siderophore Amonabactin
Cisneros Sureda, Javier; Rey-Varela, Diego; Rodríguez, Jaime; Balado, Miguel; Lemos, Manuel L.; Jiménez, Carlos (Elsevier, 2022-02-03)[Abstract] Amonabactins, the siderophores produced by some pathogenic bacteria belonging to Aeromonas genus, can be used for the preparation of conjugates to be imported into the cell using their specific transport machinery. ... -
Structural Requirements for Ga3+ Coordination in Synthetic Analogues of the Siderophore Piscibactin Deduced by Chemical Synthesis and Density Functional Theory Calculations
De la Fuente, Carmen; Ageitos, Lucía; Lages, Marta Afonso; Martínez Matamoros, Diana; Forero, Abel M.; Balado, Miguel; Lemos, Manuel L.; Rodríguez, Jaime; Jiménez, Carlos (American Chemical Society, 2023-05-04)[Abstract] Stereoselective total synthesis of several analogues of piscibactin (Pcb), the siderophore produced by different pathogenic Gram-negative bacteria, was performed. The acid-sensitive α-methylthiazoline moiety was ... -
Synthesis of Acetylhomoagmatine
Castellanos, Leonardo; Duque, Carmenza; Rodríguez, Jaime; Jiménez, Carlos (Molecular Diversity Preservation International, 2006)The first total synthesis of acetylhomoagmatine, a natural product isolated form the methanolic extracts from the sponge Cliona celata, is performed in four steps in a very high yield. -
The Fish Pathogen Vibrio ordalii Under Iron Deprivation Produces the Siderophore Piscibactin
Ruiz, Pamela; Balado, Miguel; Fuentes-Monteverde, Juan Carlos; Toranzo, Alicia E.; Rodríguez, Jaime; Jiménez, Carlos; Avendaño-Herrera, Ruben; Lemos, Manuel L. (MDPI, 2019-09-03)[Abstract] Vibrio ordalii is the causative agent of vibriosis, mainly in salmonid fishes, and its virulence mechanisms are still not completely understood. In previous works we demonstrated that V. ordalii possess several ... -
The Outer Membrane Protein FstC of Aeromonas salmonicida subsp. salmonicida Acts as Receptor for Amonabactin Siderophores and Displays a Wide Ligand Plasticity. Structure–Activity Relationships of Synthetic Amonabactin Analogues
Rey-Varela, Diego; Cisneros Sureda, Javier; Balado, Miguel; Rodríguez, Jaime; Lemos, Manuel L.; Jiménez, Carlos (American Chemical Society, 2019-09-26)[Abstract] Amonabactins are a group of four related catecholate siderophores produced by several species of the genus Aeromonas, including A. hydrophila and the fish pathogen A. salmonicida subsp. salmonicida. Although the ... -
The Siderophore Piscibactin Is a Relevant Virulence Factor for Vibrio anguillarum Favored at Low Temperatures
Balado, Miguel; Lages, Marta Afonso; Fuentes-Monteverde, Juan Carlos; Martínez Matamoros, Diana; Rodríguez, Jaime; Jiménez, Carlos; Lemos, Manuel L. (Frontiers, 2018-08-02)[Abstract] Vibrio anguillarum causes vibriosis, a hemorrhagic septicaemia that affects many cultured marine fish species worldwide. Two catechol siderophores, vanchrobactin and anguibactin, were previously identified in ... -
Thinking Outside the Blue Box: Induced Fit within a Unique Self-Assembled Polycationic Cyclophane
Blanco-Gómez, Arturo; Fernández-Blanco, Ángel; Blanco, Víctor; Rodríguez, Jaime; Peinador, Carlos; García, Marcos D. (ACS, 2019-02-07)[Abstract] We present herein the development of a new polycationic molecular receptor, inspired by the ubiquitous cyclobis(paraquat-p-phenylene)cyclophane (“blue box”). Our analogue, the “white box”, has been easily ... -
Uncovering the Cyanobacterial Chemical Diversity: The Search for Novel Anticancer Compounds
Ferreira, Leonor; Sousa, Maria Lígia; Ribeiro, Tiago; Morais, João; Forero, Abel M.; Branco, Raquel Castelo; Leão, Pedro N.; Preto, Marco Aurélio Correia; Urbatzka, Ralph; Szemerédi, Nikoletta; Spengler, Gabriella; Jiménez, Carlos; Rodríguez, Jaime; Vasconcelos, Vitor; Reis, Mariana (MDPI, 2022-09-15)[Abstract] Cancer has a tremendous negative socio-economic impact on our society. Thus, the discovery of new and more effective anticancer drugs is of utmost importance. To address this societal challenge, the main goal ... -
Vibrio neptunius Produces Piscibactin and Amphibactin and Both Siderophores Contribute Significantly to Virulence for Clams
Galvis, Fabián; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Barja, Juan L.; Lemos, Manuel L.; Balado, Miguel (Frontiers, 2021-10-25)[Abstract] Vibrio neptunius is an inhabitant of mollusc microbiota and an opportunistic pathogen causing disease outbreaks in marine bivalve mollusc species including oysters and clams. Virulence of mollusc pathogenic ...