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Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents
dc.contributor.author | Avecilla, Fernando | |
dc.contributor.author | Tariq, Saba | |
dc.contributor.author | Mondal, Neelima | |
dc.contributor.author | Azam, Amir | |
dc.contributor.author | Sharma, Guru Prasad | |
dc.date.accessioned | 2024-09-05T13:44:53Z | |
dc.date.available | 2024-09-05T13:44:53Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Tariq, S., Avecilla, F., Sharma, G. P., Mondal, N., & Azam, A. (2018). Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents. Journal of Saudi Chemical Society, 22(3), 306-315. https://doi.org/10.1016/J.JSCS.2016.05.006 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/38891 | |
dc.description.abstract | [Abstract] In an effort to develop novel antiamoebic scaffolds having better efficacy than the standard drug metronidazole (IC50 = 1.80 μM) used against Entamoeba histolytica, quinazolin-4(3H)-one Schiff base conjugates were synthesized and evaluated against HM1: IMSS strain of E. histolytica. Out of the thirteen compounds (S2-S14), six compounds (S2, S3, S4, S5, S6 and S11) were found to be better inhibitors than metronidazole and showed low cytotoxicity on HeLa cells, a cervical cancer cell line. The structure of intermediate compound S1 was confirmed by crystal structure studies. | es_ES |
dc.description.sponsorship | One of the authors S.T. is thankful to University Grant Commission, India for Maulana Azad minorities’ fellowship (SRF). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | https://doi.org/10.1016/J.JSCS.2016.05.006 | es_ES |
dc.rights | CC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.subject | Amebiasis | es_ES |
dc.subject | MTT assay | es_ES |
dc.subject | Antiamoebic activity | es_ES |
dc.subject | 1,2,4-Triazole | es_ES |
dc.title | Design, synthesis and biological evaluation of quinazolin-4(3H)-one Schiff base conjugates as potential antiamoebic agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Journal of Saudi Chemical Society | es_ES |
UDC.volume | 22 | es_ES |
UDC.issue | 3 | es_ES |
UDC.startPage | 306 | es_ES |
UDC.endPage | 315 | es_ES |
dc.identifier.doi | 10.1016/J.JSCS.2016.05.006 |