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Microbiome in Immune-Mediated Uveitis
dc.contributor.author | Poza, Margarita | |
dc.contributor.author | Rodríguez-Fernández, Carmen Antía | |
dc.contributor.author | Busto Iglesias, Manuel | |
dc.contributor.author | Domingo, Begoña de | |
dc.contributor.author | Conde-Pérez, Kelly | |
dc.contributor.author | Vallejo, J.A. | |
dc.contributor.author | Rodríguez Martínez, Lorena | |
dc.contributor.author | González Barcia, Miguel | |
dc.contributor.author | Llorenç, Victor | |
dc.contributor.author | Mondelo-García, Cristina | |
dc.contributor.author | Fernández Ferreiro, Anxo | |
dc.date.accessioned | 2024-08-28T11:08:21Z | |
dc.date.available | 2024-08-28T11:08:21Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Rodríguez-Fernández, C. A., Iglesias, M. B., de Domingo, B., Conde-Pérez, K., Vallejo, J. A., Rodríguez-Martínez, L., González-Barcia, M., Llorenç, V., Mondelo-Garcia, C., Poza, M., & Fernández-Ferreiro, A. (2022). Microbiome in Immune-Mediated Uveitis [Review of Microbiome in Immune-Mediated Uveitis]. International Journal of Molecular Sciences, 23(13). MDPI. https://doi.org/10.3390/IJMS23137020 | es_ES |
dc.identifier.uri | http://hdl.handle.net/2183/38732 | |
dc.description.abstract | [Abstract] In the last decades, personalized medicine has been increasing its presence in different fields of medicine, including ophthalmology. A new factor that can help us direct medicine towards the challenge of personalized treatments is the microbiome. The gut microbiome plays an important role in controlling immune response, and dysbiosis has been associated with immune-mediated diseases such as non-infectious uveitis (NIU). In this review, we gather the published evidence, both in the pre-clinical and clinical studies, that support the possible role of intestinal dysbiosis in the pathogenesis of NIU, as well as the modulation of the gut microbiota as a new possible therapeutic target. We describe the different mechanisms that have been proposed to involve dysbiosis in the causality of NIU, as well as the potential pharmacological tools that could be used to modify the microbiome (dietary supplementation, antibiotics, fecal microbiota transplantation, immunomodulators, or biologic drugs) and, consequently, in the control of the NIU. Furthermore, there is increasing scientific evidence suggesting that the treatment with anti-TNF not only restores the composition of the gut microbiota but also that the study of the composition of the gut microbiome will help predict the response of each patient to anti-TNF treatment. | es_ES |
dc.description.sponsorship | Funding This work was partially supported by ISCIII co-funded by FEDER (PI20/00719, PI20/00413) and by Xunta de Galicia IN607D 2021 and IN607A 2020/05. Acknowledgments CMG and AFF acknowledge the support of Instituto de Salud Carlos III (ISCIII) by research grants (JR20/0026 and JR18/00014). | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607D 2021 | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A 2020/05 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | MDPI | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00413/ES/FARMACOMICROBIOMICA Y MEDICINA PERSONALIZADA EN LA TERAPIA DEL CANCER COLORECTAL | es_ES |
dc.relation | info:eu-repo/grantAgreement/ISCIII/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PI20%2F00719/ES/MEDICINA PERSONALIZADA PARA LA OPTIMIZACION DEL TRATAMIENTO INMUNOMODULADOR EN PACIENTES CON UVEITIS (MEDPOTIV) | es_ES |
dc.relation.uri | https://doi.org/10.3390/IJMS23137020 | es_ES |
dc.rights | Creative Commons Attribution (CC BY) license 4.0 | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Non-infectious uveitis (NIU) | es_ES |
dc.subject | Immune-mediated disease | es_ES |
dc.subject | Gut microbiota | es_ES |
dc.subject | Intestinal microbiome | es_ES |
dc.subject | Ocular microbiome | es_ES |
dc.subject | Microbiota modulation | es_ES |
dc.title | Microbiome in Immune-Mediated Uveitis | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | International Journal of Molecular Sciences | es_ES |
UDC.volume | 23 | es_ES |
UDC.issue | 13 | es_ES |
UDC.startPage | Article 7020 | es_ES |
dc.identifier.doi | 10.3390/IJMS23137020 |
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