Resting metabolic rate of obese patients under very low calorie ketogenic diet
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Resting metabolic rate of obese patients under very low calorie ketogenic dietAutor(es)
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2018-02Cita bibliográfica
Gomez-Arbelaez, D., Crujeiras, A.B., Castro, A.I. et al. Resting metabolic rate of obese patients under very low calorie ketogenic diet. Nutr Metab (Lond) 15, 18 (2018). https://doi.org/10.1186/s12986-018-0249-z
Resumo
[Abstract] Background: The resting metabolic rate (RMR) decrease, observed after an obesity reduction therapy is a determinant
of a short-time weight regain. Thus, the objective of this study was to evaluate changes in RMR, and the associated
hormonal alterations in obese patients with a very low-calorie ketogenic (VLCK)-diet induced severe body weight
(BW) loss.
Method: From 20 obese patients who lost 20.2 kg of BW after a 4-months VLCK-diet, blood samples and body
composition analysis, determined by DXA and MF-Bioimpedance, and RMR by indirect calorimetry, were obtained
on four subsequent visits: visit C-1, basal, initial fat mass (FM) and free fat mass (FFM); visit C-2, − 7.2 kg in FM, − 4.
3 kg in FFM, maximal ketosis; visit C-3, − 14.4 kg FM, − 4.5 kg FFM, low ketosis; visit C-4, − 16.5 kg FM, − 3.8 kg FFM, no
ketosis. Each subject acted as his own control.
Results: Despite the large BW reduction, measured RMR varied from basal visit C-1 to visit C-2, − 1.0%; visit C-3, − 2.4%
and visit C-4, − 8.0%, without statistical significance. No metabolic adaptation was observed. The absent reduction in
RMR was not due to increased sympathetic tone, as thyroid hormones, catecholamines, and leptin were reduced at
any visit from baseline. Under regression analysis FFM, adjusted by levels of ketonic bodies, was the only predictor of
the RMR changes (R2 = 0.36; p < 0.001).
Conclusion: The rapid and sustained weight and FM loss induced by VLCK-diet in obese subjects did not induce the
expected reduction in RMR, probably due to the preservation of lean mass.
Palabras chave
Ketogenic diet
Very low-energy diet
Pronokal method
Protein diet
Obesity
Metabolic adaptation
Energy expenditure
Indirect calorimetry
DXA
Multifrequency BIA
Very low-energy diet
Pronokal method
Protein diet
Obesity
Metabolic adaptation
Energy expenditure
Indirect calorimetry
DXA
Multifrequency BIA
Versión do editor
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Atribución 3.0 España