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Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images

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NovoBujan_Jorge_2019_Automatic_segmentation_of_the_foveal_avascular_zone_in_ophthalmological_OCT_A_images.pdf (6.678Mb)
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http://hdl.handle.net/2183/37124
Atribución 3.0 España
A non ser que se indique outra cousa, a licenza do ítem descríbese como Atribución 3.0 España
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  • Investigación (FIC) [1729]
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Título
Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images
Autor(es)
Díaz González, Macarena
Novo Buján, Jorge
Cutrín, Paula
Gómez-Ulla, Francisco
Penedo, Manuel
Ortega Hortas, Marcos
Data
2019-02-22
Cita bibliográfica
Díaz M, Novo J, Cutrín P, Gómez-Ulla F, Penedo MG, Ortega M (2019) Automatic segmentation of the foveal avascular zone in ophthalmological OCT-A images. PLoS ONE 14(2): e0212364. https://doi.org/10.1371/journal.pone.0212364
Resumo
[Abstract]: Angiography by Optical Coherence Tomography (OCT-A) is a non-invasive retinal imaging modality of recent appearance that allows the visualization of the vascular structure at predefined depths based on the detection of the blood movement through the retinal vasculature. In this way, OCT-A images constitute a suitable scenario to analyze the retinal vascular properties of regions of interest as is the case of the macular area, measuring the characteristics of the foveal vascular and avascular zones. Extracted parameters of this region can be used as prognostic factors that determine if the patient suffers from certain pathologies (such as diabetic retinopathy or retinal vein occlusion, among others), indicating the associated pathological degree. The manual extraction of these biomedical parameters is a long, tedious and subjective process, introducing a significant intra and inter-expert variability, which penalizes the utility of the measurements. In addition, the absence of tools that automatically facilitate these calculations encourages the creation of computer-aided diagnosis frameworks that ease the doctor’s work, increasing their productivity and making viable the use of this type of vascular biomarkers. In this work we propose a fully automatic system that identifies and precisely segments the region of the foveal avascular zone (FAZ) using a novel ophthalmological image modality as is OCT-A. The system combines different image processing techniques to firstly identify the region where the FAZ is contained and, secondly, proceed with the extraction of its precise contour. The system was validated using a representative set of 213 healthy and diabetic OCT-A images, providing accurate results with the best correlation with the manual measurements of two experts clinician of 0.93 as well as a Jaccard’s index of 0.82 of the best experimental case in the experiments with healthy OCT-A images. The method also provided satisfactory results in diabetic OCT-A images, with a best correlation coefficient with the manual labeling of an expert clinician of 0.93 and a Jaccard’s index of 0.83. This tool provides an accurate FAZ measurement with the desired objectivity and reproducibility, being very useful for the analysis of relevant vascular diseases through the study of the retinal micro-circulation. © 2019 Díaz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Palabras chave
Case-control studies
Diabetic retinopathy
Fovea centralis
Image processing
Computer-Assisted
Ophthalmology
Tomography
Optical coherence
 
Descrición
Data Availability: All images OCT-A files are available from the OCTAGON database (http://www.varpa.org/research/ophtalmology.html) All code files are available in https://github.com/macarenadiaz/FAZ_Extraction.
Versión do editor
https://doi.org/10.1371/journal.pone.0212364
Dereitos
Atribución 3.0 España
ISSN
1932-6203

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