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Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort
dc.contributor.author | Silva-Díaz, Maite | |
dc.contributor.author | Pértega-Díaz, Sonia | |
dc.contributor.author | Balboa-Barreiro, Vanesa | |
dc.contributor.author | Tilve-Álvarez, Carlos M. | |
dc.contributor.author | Raga-Sivira, Ana | |
dc.contributor.author | Rego-Pérez, Ignacio | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Oreiro, Natividad | |
dc.date.accessioned | 2024-03-19T07:46:36Z | |
dc.date.available | 2024-03-19T07:46:36Z | |
dc.date.issued | 2024-03-12 | |
dc.identifier.citation | Silva-Díaz M, Pértega-Díaz S, Balboa-Barreiro V, Tilve-Álvarez CM, Raga-Sivira A, Rego-Pérez I, Blanco FJ, Oreiro N. Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort. Sci Rep. 2024 Mar 12;14(1):5968. | es_ES |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/2183/35924 | |
dc.description.abstract | [Abstract] To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS. | es_ES |
dc.description.sponsorship | This study was supported by grants (PI19/01206, PI20/00614, PMP22/00101, PMPTA22/00115, RICORS RD21/0002/0009 and PRB3-ISCIII-PT17/0019/0014) from Fondo de Investigacion Sanitaria, ISCIII-General Subdirection of Assessment and Promotion of Research-European Regional Development Fund (FEDER) “A way of making Europe”/“Investing in your future”. This work was also funded by Grant IN607A 2021/07 from Axencia Galega de Innovación-Xunta de Galicia. The Biomedical Research Networking Center (CIBER) is an initiative from the Instituto de Salud Carlos III (ISCIII). The authors further acknowledge AE CICA-INIBIC (ED431E 2018/03). MSD is supported by Contrato Rio Hortega Fondo de Investigacion Sanitaria (CM17/00101). | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01206/ES/VALIDACION CLINICA DE NUEVOS BIOMARCADORES PREDICTIVOS DE DIAGNOSTICO Y PRONOSTICO EN ARTROSIS: EL PROYECTO HPP | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00614/ES/IDENTIFICACION DE MUTACIONES DE ADNMT ESPECIFICAS DE ARTROSIS MEDIANTE SECUENCIACION MASIVA PARA VALORAR SU IMPACTO COMO FUTURAS DIANAS TERAPEUTICAS Y EN EL DIGANOSTICO DE FENOTIPOS | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal Para Afrontar las Prioridades de Nuestro Entorno/PMP22%2F/ES/Validación clínica del algoritmo OPTIBIO para predecir permanencia en remisión en pacientes con artritis reumatoide a tratamiento con terapia biológica (REMRABIT- plus) | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/ISCIII/Programa Estatal para Impulsar la Investigación Científico-Técnica y su Transferencia/PMPTA22€2F00115/ES/Desarrollo de estrategias de visión artificial y aprendizaje automático para la integración de imágenes multimodales con datos clínicos y moleculares en enfermedades reumáticas | es_ES |
dc.description.sponsorship | Xunta de Galicia; IN607A 2021/07 | es_ES |
dc.language.iso | spa | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation.uri | https://doi.org/10.1038/s41598-024-55374-1 | es_ES |
dc.rights | Creative Commons Attribution 4.0 International License (CC-BY 4.0) | es_ES |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Chondrocytes | es_ES |
dc.subject | Hand osteoarthritis | es_ES |
dc.subject | Knee osteoarthritis | es_ES |
dc.subject | Metabolic syndrome | es_ES |
dc.subject | Osteoarthritis | es_ES |
dc.subject | Risk | es_ES |
dc.title | Metabolic syndrome is not associated with erosive hand osteoarthritis: a cross-sectional study using data from the PROCOAC cohort | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Scientific Reports | es_ES |
UDC.volume | 14 | es_ES |
UDC.startPage | 5968 | es_ES |
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