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dc.contributor.authorMoncada-Villalobos, Danny
dc.contributor.authorRico, Maite
dc.contributor.authorMontero, Belén
dc.contributor.authorRodríguez-Llamazares, Saddys
dc.contributor.authorFeijóo-Bandín, Sandra
dc.contributor.authorGualillo, Oreste
dc.contributor.authorLago, Francisca
dc.contributor.authorAragón Herrera, Alana
dc.contributor.authorSalavagione, Horacio
dc.contributor.authorPettinelli, Natalia
dc.contributor.authorBouza, Rebeca
dc.contributor.authorFarrag, Yousof
dc.date.accessioned2023-10-18T10:09:07Z
dc.date.available2023-10-18T10:09:07Z
dc.date.issued2023-04
dc.identifier.citationD. Moncada, M. Rico, B. Montero, S. Rodríguez-Llamazares, S. Feijoo-Bandín, O. Gualillo, F. Lago, A. Aragón-Herrera, H. Salavagione, N. Pettinelli, R. Bouza, Y. Farrag, Injectable hybrid hydrogels physically crosslinked based on carrageenan and green graphene for tissue repair, International Journal of Biological Macromolecules. 235 (2023) 123777. https://doi.org/10.1016/j.ijbiomac.2023.123777.es_ES
dc.identifier.issn0141-8130
dc.identifier.urihttp://hdl.handle.net/2183/33803
dc.descriptionFinanciado para publicación en acceso aberto: Universidade da Coruña/CISUGes_ES
dc.description.abstract[Abstract] Injectable and biocompatible novel hybrid hydrogels based on physically crosslinked natural biopolymers and green graphene for potential use in tissue engineering are reported. Kappa and iota carrageenan, locust bean gum and gelatin are used as biopolymeric matrix. The effect of green graphene content on the swelling behavior, mechanical properties and biocompatibility of the hybrid hydrogels is investigated. The hybrid hydrogels present a porous network with three-dimensionally interconnected microstructures, with lower pore size than that of the hydrogel without graphene. The addition of graphene into the biopolymeric network improves the stability and the mechanical properties of the hydrogels in phosphate buffer saline solution at 37 °C without noticeable change in the injectability. The mechanical properties of the hybrid hydrogels were enhanced by varying the dosage of graphene between 0.025 and 0.075 w/v%. In this range, the hybrid hydrogels preserve their integrity during mechanical test and recover the initial shape after removing the applied stress. Meanwhile, hybrid hydrogels with graphene content of up to 0.05 w/v% exhibit good biocompatibility for 3T3-L1 fibroblasts; the cells proliferate inside the gel structure and show higher spreading after 48 h. These injectable hybrid hydrogels with graphene have promising future as materials for tissue repair.es_ES
dc.description.sponsorshipXunta de Galicia; ED431C 2019/17es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; CD21/00042es_ES
dc.description.sponsorshipChile. CORFO; 22CVID-206836es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.urihttps://doi.org/10.1016/j.ijbiomac.2023.123777es_ES
dc.rightsCC BY license http://creativecommons.org/licenses/by/4.0/es_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectInjectable hydrogelses_ES
dc.subjectCarrageenanes_ES
dc.subjectGraphenees_ES
dc.titleInjectable hybrid hydrogels physically crosslinked based on carrageenan and green graphene for tissue repaires_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleInternational Journal of Biological Macromoleculeses_ES
UDC.volume235es_ES
UDC.issue123777es_ES
UDC.startPage1es_ES
UDC.endPage9es_ES
dc.identifier.doihttps://doi.org/10.1016/j.ijbiomac.2023.123777


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