Predicting pharmaceutical inkjet printing outcomes using machine learning
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Predicting pharmaceutical inkjet printing outcomes using machine learningAuthor(s)
Date
2023Citation
P. Carou-Senra et al., "Predicting pharmaceutical inkjet printing outcomes using machine learning", International Journal of Pharmaceutics: X, 5, 2023. doi:10.1016/j.ijpx.2023.100181
Abstract
[Abstract]: Inkjet printing has been extensively explored in recent years to produce personalised medicines due to its low cost and versatility. Pharmaceutical applications have ranged from orodispersible films to complex polydrug implants. However, the multi-factorial nature of the inkjet printing process makes formulation (e.g., composition, surface tension, and viscosity) and printing parameter optimization (e.g., nozzle diameter, peak voltage, and drop spacing) an empirical and time-consuming endeavour. Instead, given the wealth of publicly available data on pharmaceutical inkjet printing, there is potential for a predictive model for inkjet printing outcomes to be developed. In this study, machine learning (ML) models (random forest, multilayer perceptron, and support vector machine) to predict printability and drug dose were developed using a dataset of 687 formulations, consolidated from in-house and literature-mined data on inkjet-printed formulations. The optimized ML models predicted the printability of formulations with an accuracy of 97.22%, and predicted the quality of the prints with an accuracy of 97.14%. This study demonstrates that ML models can feasibly provide predictive insights to inkjet printing outcomes prior to formulation preparation, affording resource- and time-savings.
Keywords
2D and 3D printed drug products
Additive manufacturing and personalized medications
Artificial intelligence and digital health
Design and fabrication of medicinal products
Desktop ink jet printing of pharmaceuticals and drug delivery systems
Rational formulation development
Additive manufacturing and personalized medications
Artificial intelligence and digital health
Design and fabrication of medicinal products
Desktop ink jet printing of pharmaceuticals and drug delivery systems
Rational formulation development
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Atribución 4.0 Internacional (CC BY 4.0)