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dc.contributor.authorLópez-Armada, María José
dc.contributor.authorFernández-Rodríguez, Jennifer Adriana
dc.contributor.authorBlanco García, Francisco J
dc.date.accessioned2022-07-12T08:39:02Z
dc.date.available2022-07-12T08:39:02Z
dc.date.issued2022-06-12
dc.identifier.citationLópez-Armada MJ, Fernández-Rodríguez JA, Blanco FJ. Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis. Antioxidants (Basel). 2022 Jun 12;11(6):1151.es_ES
dc.identifier.issn2076-3921
dc.identifier.urihttp://hdl.handle.net/2183/31161
dc.descriptionReviewes_ES
dc.description.abstract[Abstract] Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an inflammatory scenario, such as rheumatoid arthritis (RA). Increasing evidence has demonstrated the role of mitochondrial alterations in autoimmune diseases mainly due to the interplay between metabolism and innate immunity, but also in the modulation of inflammatory response of resident cells, such as synoviocytes. Thus, mitochondrial dysfunction derived from several danger signals could activate tricarboxylic acid (TCA) disruption, thereby favoring a vicious cycle of oxidative/mitochondrial stress. Mitochondrial dysfunction can act through modulating innate immunity via redox-sensitive inflammatory pathways or direct activation of the inflammasome. Besides, mitochondria also have a central role in regulating cell death, which is deeply altered in RA. Additionally, multiple evidence suggests that pathological processes in RA can be shaped by epigenetic mechanisms and that in turn, mitochondria are involved in epigenetic regulation. Finally, we will discuss about the involvement of some dietary components in the onset and progression of RA.es_ES
dc.description.sponsorshipThis work has been supported by grants from Fondo Investigación Sanitaria-Spain (PI17/00404, PI18/01803, PI19/01206, PI20/00793, PI21/01969 and RICORS RD21/0002/0009), integrated in the National Plan for Scientific Program, Development and Technological Innovation 2013–2016 and funded by the ISCIII-General Subdirection of Assessment and Promotion of Research-European Regional Development Fund (FEDER) “A way of making Europe”. This study is also supported by grants IN607A2017/11 and IN607D2020/10 from Xunta de Galicia.es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI17%2F00404/ES/IDENTIFICACION Y VALIDACION DE BIOMARCADORES CIRCULANTES PREDICTIVOS DE RESPUESTA A ESTRATEGIAS DE TERAPIA BIOLOGICA EN PACIENTES CON ARTRITIS REUMATOIDE (BIO-RESTER)es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI18%2F01803/ES/PAPEL DE LA AUTOFAGIA EN EL REMODELADO DE LA MEMBRANA PERITONEAL ASOCIADO A PACIENTES TRATADOS CON DIALISIS PERITONEAL. EFECTO DE UNA DIETA ANTIOXIDANTE.es_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01206/ES/VALIDACION CLINICA DE NUEVOS BIOMARCADORES PREDICTIVOS DE DIAGNOSTICO Y PRONOSTICO EN ARTROSIS: EL PROYECTO HPPes_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI20%2F00793/ES/DESARROLLO DE SOLUCIONES INTEGRADAS DE ANALITICA PREDICTIVA PARA PERSONALIZAR LA FARMACOTERAPIA EN PACIENTES CON ARTRITIS REUMATOIDEes_ES
dc.description.sponsorshipinfo:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI21%2F01969/ES/ESTUDIO DE LA RELACION ENTRE LA DISFUNCION MITOCONDRIAL Y LA ACTIVACIÓN INFLAMATORIA EN CELULAS MONONUCLEARES DE SANGRE PERIFÉRICA EN LA ARTRITIS REUMATOIDE. EFECTO DE UNA DIETA ANTIOXIDANTE.es_ES
dc.description.sponsorshipXunta de Galicia; IN607A2017/11es_ES
dc.description.sponsorshipXunta de Galicia; IN607D2020/10es_ES
dc.description.sponsorshipInstituto de Salud Carlos III; RD21/0002/0009
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation.urihttps://doi.org/10.3390/antiox11061151es_ES
dc.rightsCreative Commons Attribution 4.0 International License (CC-BY 4.0)es_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCell deathes_ES
dc.subjectDietes_ES
dc.subjectEpigenetices_ES
dc.subjectInflammationes_ES
dc.subjectMetabolismes_ES
dc.subjectMitochondriaes_ES
dc.subjectOxidative stresses_ES
dc.subjectRheumatoid arthritises_ES
dc.titleMitochondrial dysfunction and oxidative stress in rheumatoid arthritises_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleAntioxidantses_ES
UDC.volume11es_ES
UDC.issue6es_ES
UDC.startPage1151es_ES


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