Listar Nanochemistry and Self-Assembly for Biological Sciences (NANOSELF4BIO) por autor "Madry, Henning"
Mostrando ítems 1-4 de 4
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Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Schmitt, Gertrud; Speicher-Mentges, Susanne; Falentin-Daudré, Céline; Leroux, Amélie; Madry, Henning; Migonney, Véronique; Cucchiarini, Magali (MDPI, 2020)[Abstract] Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
Rey-Rico, Ana; Madry, Henning; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cai, Xiaoyu; Meng, Weikun; Cucchiarini, Magali; Maihöfer, Johanna; Goebel, Lars; Zurakowski, David; Menger, Michael D.; Laschke, Matthias W. (Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Cucchiarini, Magali; Madry, Henning; Gardner, Oliver; Eglin, David; Alini, Mauro; Stoddart, Martin J. (MDPI, 2018)[Abstract] The repair of focal articular cartilage defects remains a problem. Combining gene therapy with tissue engineering approaches using bone marrow-derived mesenchymal stem cells (MSCs) may allow the development of ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
Madry, Henning; Rey-Rico, Ana; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cucchiarini, Magali; Goebel, Lars; Zurakowski, David; Laschke, Matthias W.; Cai, Xiaoyu; Menger, Michael D.; Gao, Liang; Müller-Brandt, Kathrin (WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...