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A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score

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Title
A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score
Author(s)
Barrios, Vivencio
Escobar, Carlos
Prieto, Luis
Polo, Jose
Muñiz, Javier
Anguita, Manuel
Lip, Gregory Y.H.
Date
2020-12-17
Citation
Barrios V, Escobar C, Prieto L, Polo J, Muñiz J, Anguita M, et al. A new index to predict quality of anticoagulation control in patients on vitamin K antagonists: the DAFNE score. Future Cardiol. 2021;17(4):685-692
Abstract
[Abstract] Aim: To derive a new clinical score to improve the prediction of those at risk of poor International Normalized Ratio control among patients with atrial fibrillation taking vitamin K antagonists. Materials & methods: The score was calculated using PAULA database and validated in the FANTASIIA population. Results: The DAFNE score (cardiovascular Disease, concomitant treatment with Amiodarone, Food/dietary transgression and taking ≥7 pills daily, fEemale sex) score was related to a higher probability of poor International Normalized Ratio control. C-indexes were 0.611 and 0.576 (De Long test, p = 0.007) for the DAFNE and SAMe-TT2R2 scores, respectively. Conclusion: The DAFNE score is a new clinical score which may potentially help determine those patients with atrial fibrillation who are at high risk of poor anticoagulation control with vitamin K antagonists.
Keywords
INR
SAMe-TT2R2
Anticoagulation
Atrial fibrillation
Control
Vitamin K antagonists
 
Editor version
https://doi.org/10.2217/fca-2020-0122
ISSN
1479-6678

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