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Oral Bioavailability Reveals an Overestimation of the Toxicity of Polycyclic Aromatic Hydrocarbons in Atmospheric Particulate Matter
dc.contributor.author | Sánchez-Piñero, Joel | |
dc.contributor.author | Gómez-Meijide, Paula | |
dc.contributor.author | Concha-Graña, Estefanía | |
dc.contributor.author | Moreda-Piñeiro, Jorge | |
dc.contributor.author | Muniategui, Soledad | |
dc.contributor.author | López-Mahía, P. | |
dc.date.accessioned | 2022-03-08T13:40:41Z | |
dc.date.available | 2022-03-08T13:40:41Z | |
dc.date.issued | 2021-11-19 | |
dc.identifier.citation | Sánchez-Piñero, J., Gómez-Meijide, P., Concha-Graña, E. et al. Oral bioavailability reveals an overestimation of the toxicity of polycyclic aromatic hydrocarbons in atmospheric particulate matter. Environ Chem Lett 20, 49–57 (2022). https://doi.org/10.1007/s10311-021-01354-0 | es_ES |
dc.identifier.issn | 1610-3653 | |
dc.identifier.uri | http://hdl.handle.net/2183/29908 | |
dc.description | Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG | es_ES |
dc.description.abstract | [Abstract] Polycyclic aromatic hydrocarbons (PAHs) in atmospheric particulate matter have adverse effects on human health, yet total PAH concentrations should overestimate the toxicity compared to the bioavailable amount of PAHs. To explore this hypothesis, we measured PAHs oral bioavailability in vitro in particulate matter with aerodynamic diameter lower than 10 µm (PM₁₀) using a test that mimics the human digestive system. This assay combines the use of simulated gastrointestinal fluids and a dialysis membrane to simulate intestinal absorption. Results show that oral PAH bioavailability was below 5%, with fluorene, anthracene, acenaphthene and phenanthrene as the most bioavailable PAHs. Data suggest no carcinogenic risk of oral bioavailable PM₁₀-bound PAHs following a health risk assessment via inhalation-ingestion by using benzo(a)pyrene-equivalent carcinogenic concentration and hazard indexes. To our best knowledge, this is the first research study of in vitro oral bioavailability estimation of PM₁₀-associated PAHs. | es_ES |
dc.description.sponsorship | This work was supported by Ministerio de Ciencia, Innovación y Universidades (MCIU), Agencia Estatal de Investigación (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (Programa Estatal de I+D+i Orientada a los Retos de la Sociedad, ref: RTI 2018-101116-B-I00) and Xunta de Galicia (Programa de Consolidación y Estructuración de Unidades de Investigación Competitivas ref: ED431C 2017/28-2017-2020). Joel Sánchez-Piñero acknowledges the Xunta de Galicia and the European Union (European Social Fund—ESF) for a predoctoral grant (ED481A-2018/164). The council of A Coruña is acknowledged for its assistance (collaboration agreement between the City of A Coruña and the University Institute of Environment (IUMA) of the University of A Coruña (UDC) for the measurement of PM10 particle levels in the area of Os Castros, A Coruña). The authors would like to thank EXPRELA group (UDC) for their support. Funding for open access charge: Universidade da Coruña/CISUG | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431C 2017/28-2017-2020 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED481A-2018/164 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Springer Nature | es_ES |
dc.relation | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RTI 2018-101116-B-I00/ES/BIODISPONIBIIDAD IN-VITRO DE CONTAMINANTES PRIORITARIOS EN MATERIA PARTICULADA ATMOSFERICA. EVALUACION DE RIESGOS PARA LA SALUD Y PREDICCION DE LA TOXICIDAD/ | |
dc.relation.uri | https://doi.org/10.1007/s10311-021-01354-0 | es_ES |
dc.rights | Atribución 4.0 Internacional | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Oral bioavailability | es_ES |
dc.subject | Polycyclic aromatic hydrocarbons | es_ES |
dc.subject | Particulate matter | es_ES |
dc.subject | Physiologically based extraction | es_ES |
dc.subject | Health risk assessment | es_ES |
dc.title | Oral Bioavailability Reveals an Overestimation of the Toxicity of Polycyclic Aromatic Hydrocarbons in Atmospheric Particulate Matter | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Environmental Chemistry Letters | es_ES |
UDC.volume | 20 | es_ES |
UDC.startPage | 49 | es_ES |
UDC.endPage | 57 | es_ES |
dc.identifier.doi | 10.1007/s10311-021-01354-0 |
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