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Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes
dc.contributor.author | Piñeiro-Ramil, María | |
dc.contributor.author | Flórez-Fernández, Noelia | |
dc.contributor.author | Ramil-Gómez O | |
dc.contributor.author | Torres, María Dolores | |
dc.contributor.author | Domínguez, Herminia | |
dc.contributor.author | Blanco García, Francisco J | |
dc.contributor.author | Meijide-Faílde, Rosa | |
dc.contributor.author | Vaamonde-García, Carlos | |
dc.date.accessioned | 2022-01-20T08:04:39Z | |
dc.date.available | 2022-01-20T08:04:39Z | |
dc.date.issued | 2022-01-12 | |
dc.identifier.citation | PiPiñeiro-Ramil M, Flórez-Fernández N, Ramil-Gómez O, Torres MD, Dominguez H, Blanco FJ, Meijide-Faílde R, Vaamonde-García C. Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes. Carbohydr Polym. 2022 Apr;282:119134. | es_ES |
dc.identifier.issn | 0144-8617 | |
dc.identifier.uri | http://hdl.handle.net/2183/29448 | |
dc.description | Financiado para publicación en acceso aberto: Universidade da Coruña/CISUG | |
dc.description.abstract | [Abstract] Synovial fibrosis is a pathological process which contributes to joint pain and stiffness in several musculoskeletal disorders. Fucoidans, sulfated polysaccharides found in brown algae, have recently emerged as promising therapeutic agents. Despite the increasing amount of evidence suggesting the protective role of fucoidans in different experimental approaches of human fibrotic disorders, the effect of these sulfated polysaccharides on synovial fibrosis has not been investigated yet. By an in vitro experimental approach in fibroblast-like synoviocytes, we detected that fucoidans inhibit their differentiation into myofibroblasts with tumor cell-like characteristics and restore apoptosis. Composition and structure of fucoidan appear to be critical for the detected activity. Furthermore, protective effects of these sulfated polysaccharides are mediated by upregulation of nitric oxide production and modulation of TGF-β/smad pathway. Altogether, our results support the use of fucoidans as therapeutic compounds in the treatment of the fibrotic processes involved in rheumatic pathologies. | es_ES |
dc.description.sponsorship | Financial support from the Xunta de Galicia and the European Union (European Regional Development Fund - ERDF) is gratefully acknowledged (Grupos con Potencial de Crecemento 2020, grant number ED431B 2020/55; Centro Singular de Investigación de Galicia 2019–2022, grant number ED431G2019/06; Rede Galega de Terapia Celular 2016, grant number R2016/036). N.F.-F. thanks Xunta de Galicia for her postdoctoral contract [grant number ED481B 2018/071]. M.D.T. thanks Ministry of Economy and Competitiveness of Spain for her postdoctoral grant [grant number RYC2018-024454-I]. C.V.-G. thanks Xunta de Galicia for his postdoctoral contract [grant number ED481D 2017/023]. Authors also thank Universidade da Coruña/CISUG for funding open access charge | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431B 2020/55 | es_ES |
dc.description.sponsorship | Xunta de Galicia; ED431G 2019/06 | es_ES |
dc.description.sponsorship | Xunta de Galicia; R2016/036 | |
dc.description.sponsorship | Xunta de Galicia; ED481B 2018/071 | |
dc.description.sponsorship | Xunta de Galicia; ED481D 2017/023 | |
dc.description.sponsorship | Ministerio de Economía y Competitividad (España); RYC2018-024454-I | |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation.uri | https://doi.org/10.1016/j.carbpol.2022.119134 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International Licence (CC-BY-NC-ND 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | * |
dc.subject | Fucoidan | es_ES |
dc.subject | Transforming growth factor beta | es_ES |
dc.subject | Fibrosis | es_ES |
dc.subject | Synovial fibroblasts | es_ES |
dc.subject | Apoptosis | es_ES |
dc.subject | Nitric oxide | es_ES |
dc.title | Antifibrotic effect of brown algae-derived fucoidans on osteoarthritic fibroblast-like synoviocytes | es_ES |
dc.type | journal article | es_ES |
dc.rights.accessRights | open access | es_ES |
UDC.journalTitle | Carbohydrate Polymers | es_ES |
UDC.volume | 282 | es_ES |
UDC.startPage | 119134 | es_ES |
dc.identifier.doi | 10.1016/j.carbpol.2022.119134 | |
UDC.coleccion | Investigación | es_ES |
UDC.departamento | Fisioterapia, Medicina e Ciencias Biomédicas | es_ES |
UDC.grupoInv | Grupo de Investigación en Reumatoloxía e Saúde (GIR-S) | es_ES |
UDC.grupoInv | Reumatoloxía (INIBIC) | es_ES |
UDC.institutoCentro | INIBIC - Instituto de Investigacións Biomédicas de A Coruña | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/RYC2018-024454-I/ES/ |
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