Listar GI-REACT! - Artigos por autor "Uzal-Varela, Rocío"

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    • A Pentadentate Member of the Picolinate Family for Mn(ɪɪ) Complexation and an Amphiphilic Derivative 

      Pujales-Paradela, Rosa; Carniato, Fabio; Uzal-Varela, Rocío; Brandariz, Isabel; Iglesias, Emilia; Platas-Iglesias, Carlos; Botta, Mauro; Esteban-Gómez, David (Royal Society of Chemistry, 2018-12-04)
      [Abstract] We report a pentadentate ligand containing a 2,2′-azanediyldiacetic acid moiety functionalized with a picolinate group at the nitrogen atom (H3paada), as well as a lipophylic derivative functionalized with a ...

    • Expanding the Ligand Classes Used for Mn(II) Complexation: Oxa-aza Macrocycles Make the Difference 

      Kálmán, Ferenc; Nagy, Viktória; Uzal-Varela, Rocío; Pérez-Lourido, Paulo; Esteban-Gómez, David; Garda, Zoltán; Pota, Kristof; Mezei, Roland; Pallier, Agnès; Tóth, Éva; Platas-Iglesias, Carlos; Tircsó, Gyula (MDPI, 2021-03-10)
      [Abstract] We report two macrocyclic ligands based on a 1,7-diaza-12-crown-4 platform functionalized with acetate (𝑡O2DO2A²⁻) or piperidineacetamide (𝑡O2DO2AMᴾⁱᵖ) pendant arms and a detailed characterization of the ...

    • On the Dissociation Pathways of Copper Complexes Relevant as Pet Imaging Agents 

      Uzal-Varela, Rocío; Patinec, Véronique; Tripier, Raphaël; Valencia, Laura; Maneiro, Marcelino; Canle, Moisés; Platas-Iglesias, Carlos; Esteban-Gómez, David; Iglesias, Emilia (Elsevier, 2022)
      [Abstract] Several bifunctional chelators have been synthesized in the last years for the development of new 64Cu-based PET agents for in vivo imaging. When designing a metal-based PET probe, it is important to achieve ...

    • Thermodynamic Stability of Mn(II) Complexes with Aminocarboxylate Ligands Analyzed Using Structural Descriptors 

      Uzal-Varela, Rocío; Pérez-Fernández, Francisco; Valencia, Laura; Rodríguez-Rodríguez, Aurora; Platas-Iglesias, Carlos; Caravan, Peter; Esteban-Gómez, David (ACS, 2022-08-22)
      [Abstract] We present a quantitative analysis of the thermodynamic stabilities of Mn(II) complexes, defined by the equilibrium constants (log KMnL values) and the values of pMn obtained as −log[Mn]free for total metal and ...

    • Understanding the Effect of the Electron Spin Relaxation on the Relaxivities of Mn(II) Complexes with Triazacyclononane Derivatives 

      Uzal-Varela, Rocío; Valencia, Laura; Lalli, Daniela; Maneiro, Marcelino; Esteban-Gómez, David; Platas-Iglesias, Carlos; Botta, Mauro; Rodríguez-Rodríguez, Aurora (American Chemical Society, 2021-10-07)
      [Abstract] Investigating the relaxation of water ¹H nuclei induced by paramagnetic Mn(II) complexes is important to understand the mechanisms that control the efficiency of contrast agents used in diagnostic magnetic ...