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dc.contributor.authorBaranyai, Zsolt
dc.contributor.authorCarniato, Fabio
dc.contributor.authorNucera, Alessandro
dc.contributor.authorHorváth, Dávid
dc.contributor.authorTei, Lorenzo
dc.contributor.authorPlatas-Iglesias, Carlos
dc.contributor.authorBotta, Mauro
dc.date.accessioned2021-10-01T11:19:20Z
dc.date.available2021-10-01T11:19:20Z
dc.date.issued2021-07-26
dc.identifier.citation1 Z. Baranyai, F. Carniato, A. Nucera, D. Horváth, L. Tei, C. Platas-Iglesias and M. Botta, Chem. Sci., 2021, 12, 11138–11145.es_ES
dc.identifier.issn2041-6539
dc.identifier.urihttp://hdl.handle.net/2183/28551
dc.descriptionElectronic supplementary information (ESI) available: Experimental details: thermodynamic, kinetic and redox studies. Equations used, NMRD profiles and DFT optimized structures. See DOI: 10.1039/d1sc02200h
dc.description.abstract[Abstract] Fe(III) complexes are attracting growing interest in chemists developing diagnostic probes for Magnetic Resonance Imaging because they leverage on an endogenous metal and show superior stability. However, in this case a detailed understanding of the relationship between the chemical structure of the complexes, their magnetic, thermodynamic, kinetic and redox properties and the molecular parameters governing the efficacy (relaxivity) is still far from being available. We have carried out an integrated ¹H and ¹⁷O NMR relaxometric study as a function of temperature and magnetic field, on the aqua ion and three complexes chosen as reference models, together with theoretical calculations, to obtain accurate values of the parameters that control their relaxivity. Moreover, thermodynamic stability and dissociation kinetics of the Fe(III) chelates, measured in association with the ascorbate reduction behaviour, highlight their role and mutual influence in achieving the stability required for use in vivo.es_ES
dc.description.sponsorshipF. C., L. T. and M. B. acknowledge the financial support from Università del Piemonte Orientale (Ricerca locale FAR2019). C.P.-I. thanks Ministerio de Economía y Competitividad (CTQ2016-76756-P) and Xunta de Galicia (ED431B 2020/52) for generous financial support. C.P.-I. also thanks Centro de Supercomputación de Galicia (CESGA) for providing the computer facilities. Z. B. thanks the Doctoral School of Chemistry of the University of Debrecen for the PhD position of D. H. This work was carried out within the framework of the COST CA15209 Action “European Network on NMR Relaxometry”es_ES
dc.description.sponsorshipXunta de Galicia; ED431B 2020/52es_ES
dc.description.urihttps://www.rsc.org/suppdata/d1/sc/d1sc02200h/d1sc02200h1.pdf?_ga=2.73863058.1846997019.1635238700-352143482.1630049716
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relationinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/CTQ2016-76756-P/ES/NUEVA GENERACION DE AGENTES DE CONTRASTE PARA IMAGEN POR RESONANCIA MAGNETICA (IRM) ALTERNATIVOS A LOS DERIVADOS DE GADOLINIO/
dc.relation.urihttps://doi.org/10.1039/D1SC02200Hes_ES
dc.rightsAtribución-NoComercial 3.0es_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/*
dc.titleDefining the Conditions for the Development of the Emerging Class of Feᴵᴵᴵ-Based MRI Contrast Agentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleChemical Sciencees_ES
UDC.volume12es_ES
UDC.issue33es_ES
UDC.startPage11138es_ES
UDC.endPage11145es_ES
dc.identifier.doi10.1039/D1SC02200H


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