Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight loss
![Thumbnail](/dspace/bitstream/handle/2183/25278/JuizVali%c3%b1a_Paula_2020_Central_resistance_thyroid_hormones.pdf.jpg?sequence=5&isAllowed=y)
Use este enlace para citar
http://hdl.handle.net/2183/25278
A non ser que se indique outra cousa, a licenza do ítem descríbese como Creative Commons Attribution 4.0 International License (CC-BY 4.0)
Coleccións
- GI-FENM - Artigos [114]
- INIBIC-EENM - Artigos [52]
Metadatos
Mostrar o rexistro completo do ítemTítulo
Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight lossAutor(es)
Data
2020-01-28Cita bibliográfica
Juiz-Valiña P, Cordido M, Outeiriño-Blanco E, Pértega S, Varela-Rodríguez BM, García-Brao MJ, Mena E, Pena-Bello L, Sangiao-Alvarellos S, Cordido F. Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight loss. J Clin Med. 2020 Jan 28;9(2):359.
Resumo
[Abstract]
Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study was to investigate the effect of weight loss after bariatric surgery (BS) on resistance to thyroid hormones in patients with extreme obesity compared with a control group. We performed an observational study evaluating patients with extreme obesity who underwent BS. We included 106 patients (83 women) and 38 controls (24 women). The primary endpoint was the thyrotroph thyroxine resistance index (TT4RI) and thyroid stimulating hormone (TSH) index (TSHRI). The parameters were studied before and after surgery. TSHRI and TT4RI were higher in the obese patients than in the control group. TT4RI and TSHI decreased significantly over time after surgery, with this decrease being associated with the excessive body mass index (BMI) loss and C-reactive protein (CRP). In extreme obesity, BS promotes a significant decrease in the increased TT4RI and TSHI. This decrease of TT4RI and TSHI is progressive over time after BS and significantly associated with excess BMI lost and CRP. Extreme obesity is characterized by a mild reversible central resistance to thyroid hormones.
Palabras chave
Obesity
Bariatric surgery
Endocrine abnormalities
Thyroid hormone resistance
Bariatric surgery
Endocrine abnormalities
Thyroid hormone resistance
Versión do editor
Dereitos
Creative Commons Attribution 4.0 International License (CC-BY 4.0)
ISSN
2077-0383