Mostrar o rexistro simple do ítem
Gonadotrophin-releasing hormone agonist-induced pituitary adenoma apoplexy and casual finding of a parathyroid carcinoma: a case report and review of literature
dc.contributor.author | Triviño, Vanessa | |
dc.contributor.author | Fidalgo, Olga | |
dc.contributor.author | Juane, Antía | |
dc.contributor.author | Pombo-Otero, Jorge | |
dc.contributor.author | Cordido, Fernando | |
dc.date.accessioned | 2020-01-14T10:56:29Z | |
dc.date.available | 2020-01-14T10:56:29Z | |
dc.date.issued | 2019-10-26 | |
dc.identifier.citation | Triviño V, Fidalgo O, Juane A, Pombo J, Cordido F. Gonadotrophin-releasing hormone agonist-induced pituitary adenoma apoplexy and casual finding of a parathyroid carcinoma: a case report and review of literature. World J Clin Cases. 2019; 7(20):3259-3265 | es_ES |
dc.identifier.issn | 2307-8960 | |
dc.identifier.uri | http://hdl.handle.net/2183/24617 | |
dc.description.abstract | [Absatract] BACKGROUND Pituitary apoplexy represents one of the most serious, life threatening endocrine emergencies that requires immediate management. Gonadotropin-releasing hormone agonist (GnRHa) can induce pituitary apoplexy in those patients who have insidious pituitary adenoma coincidentally. CASE SUMMARY A 46-year-old woman, with a history of hypertension and menorrhagia was transferred to our hospital from a secondary care hospital after complaints of headache and vomiting, with loss of consciousness 5 min after an injection of GnRHa. The drug was prescribed by her gynecologist due to the presence of uterine myomas. The clinical neurological examination revealed right cranial nerve III palsy, ptosis and movement limitation of the right eye. Our first clinical consideration was a pituitary apoplexy. Blood hormonal analysis revealed mild hyperprolactinemia and high follicle stimulating hormone level; PTH and calcium was high with glomerular filtration rate mildly to moderately decrease. A computed tomography scan, revealed an enlarged pituitary gland (3.5 cm) impinging upon the optic chiasm with bone involvement of the sella. Following contrast media administration, the lesion showed homogeneous enhancement with high-density focus that suggests hemorrhagic infarction of the tumor. Transsphenoidal endoscopic surgery was perfomed and adenomatous tissue was removed. Immunohistochemistry was positive for luteinizing hormone (LH) and follicular-stimulating hormone (FSH). A solid hypoechoic nodule (14 mm x 13 mm x 16 mm) was found in the caudal portion of the right thyroid lobe after a parathyroid ultrasound. A genetic test of Multiple Endocrine Neoplasia type 1 (MEN1) was negative. A right lower parathyroidectomy was performed and the pathologic study showed the presence of an encapsulated parathyroid carcinoma of 1.5 cm. A MEN type 4 genetic test was performed result was negative. CONCLUSION This case demonstrates an uncommon complication of GnRH agonist therapy in the setting of a pituitary macroadenoma and the casual finding of parathyroid carcinoma. It also highlights the importance of suspecting the presence of a multiple endocrine neoplasia syndrome and to carry out relevant genetic studies. | es_ES |
dc.description.sponsorship | info:eu-repo/grant Agreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI13%2F00322/ES/EVOLUCION DE LAS HORMONAS GASTROINTESTINALES TRAS LA DISMINUCION DE LA ADIPOSIDAD Y LA MODIFICACIÓN DE LOS NIVELES DE GH. EL EJE CEREBRO-INTESTINO | es_ES |
dc.description.sponsorship | info:eu-repo/grantAgreement/MINECO/Programa Estatal de I+D+I Orientada a los Retos de la Sociedad/PI16%2F00884/ES/RELACION ENTRE MARCADORES HORMONALES DE CONTROL DE LA INGESTA Y GASTO METABÓLICO. EFECTO DEL BALANCE ENERGÉTICO NEGATIVO Y LA MODIFICACIÓN DE GH | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Baishideng Publishing Group | es_ES |
dc.relation.uri | https://doi.org/10.12998/wjcc.v7.i20.3259 | es_ES |
dc.rights | Creative Commons Attribution-NonCommercial 4.0 International License (CC-BY-NC 4.0) | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | * |
dc.subject | Pituitary apoplexy | es_ES |
dc.subject | Pituitary adenoma | es_ES |
dc.subject | Primary hyperparathyroidism | es_ES |
dc.subject | MEN type 1 | es_ES |
dc.subject | MEN type 4 | es_ES |
dc.subject | Parathyroid carcinoma | es_ES |
dc.subject | Case report | es_ES |
dc.title | Gonadotrophin-releasing hormone agonist-induced pituitary adenoma apoplexy and casual finding of a parathyroid carcinoma: a case report and review of literature | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | World Journal of Clinical Cases | es_ES |
UDC.volume | 7 | es_ES |
UDC.issue | 20 | es_ES |
UDC.startPage | 3259 | es_ES |
UDC.endPage | 3265 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-FENM - Artigos [119]
-
INIBIC-EENM - Artigos [52]