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Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles
dc.contributor.author | Benyettou, Farah | |
dc.contributor.author | Fahs, H. | |
dc.contributor.author | Elkharrag, R. | |
dc.contributor.author | Bilbeisi, Rana A. | |
dc.contributor.author | Asmaa, Bouakaz | |
dc.contributor.author | Rezgui, Rachid | |
dc.contributor.author | Motte, Laurence | |
dc.contributor.author | Magzoub, Mazin | |
dc.contributor.author | Brandel, J. | |
dc.contributor.author | Olsen, John-Carl | |
dc.contributor.author | Piano, F. | |
dc.contributor.author | Gunsalus, K. C. | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.contributor.author | Trabolsi, Ali | |
dc.date.accessioned | 2019-11-05T13:53:48Z | |
dc.date.available | 2019-11-05T13:53:48Z | |
dc.date.issued | 2017-05-03 | |
dc.identifier.citation | 1 F. Benyettou, H. Fahs, R. Elkharrag, R. A. Bilbeisi, B. Asma, R. Rezgui, L. Motte, M. Magzoub, J. Brandel, J. C. Olsen, F. Piano, K. C. Gunsalus, C. Platas-Iglesias and A. Trabolsi, RSC Adv., 2017, 7, 23827–23834. | es_ES |
dc.identifier.issn | 2046-2069 | |
dc.identifier.uri | http://hdl.handle.net/2183/24243 | |
dc.description.abstract | [Abstract] Cucurbit[7]uril-modified iron-oxide nanoparticles (CB[7]NPs) were loaded with doxorubicin hydrochloride (Dox) and tested as a drug delivery system. Dox was found to interact with the carbonyl-rich rims of the CB[7] macrocycles adsorbed on the surface of the nanoparticles. The Dox-loaded nanoparticles (Dox@CB[7]NPs) were stable at room temperature and physiological pH and released their Dox cargo under acidic conditions, in the presence of glutathione, or with heating. Dox@CB[7]NPs reduced the viability of HeLa and three other cancer-derived cell lines in vitro at lower IC50 than free Dox. They were also nontoxic to C. elegans. The sensitivity of HeLa cells to Dox@CB[7]NPs was enhanced when the temperature was elevated by application of an alternating magnetic field. Thus, Dox@CB[7]NPs show promise as agents for the intracellular delivery of Dox to cancer cells, for the selective and controlled release of the drug, and, more generally, as a possible means of combining chemotherapeutic and hyperthermic treatment modalities. | es_ES |
dc.description.sponsorship | Al Jalila Foundation; AJF 201425 | es_ES |
dc.description.sponsorship | Al Jalila Foundation; AJF 201538 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation.uri | http://doi.org/10.1039/C7RA02693E | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/es/ | * |
dc.subject | Iron oxide | es_ES |
dc.subject | Doxorubicin | es_ES |
dc.subject | Curcubit[7]uril | es_ES |
dc.subject | Cancer | es_ES |
dc.subject | Hyperthermia | es_ES |
dc.title | Selective growth inhibition of cancer cells with doxorubicin-loaded CB[7]-modified iron-oxide nanoparticles | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | RSC Advances | es_ES |
UDC.volume | 7 | es_ES |
UDC.issue | 38 | es_ES |
UDC.startPage | 23827 | es_ES |
UDC.endPage | 23834 | es_ES |
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