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dc.contributor.authorCakic, Nevenka
dc.contributor.authorVerbić, Tatjana Ž.
dc.contributor.authorJelić, Ratomir M.
dc.contributor.authorPlatas-Iglesias, Carlos
dc.contributor.authorAngelovski, Goran
dc.date.accessioned2019-11-05T11:53:03Z
dc.date.available2019-11-05T11:53:03Z
dc.date.issued2016-02-26
dc.identifier.citationN. Cakić, T. Verbić, R. M. Jelić, C. Platas-Iglesias and G. Angelovski, Dalt. Trans., 2016, 45, 6555–6565.es_ES
dc.identifier.issn1477-9234
dc.identifier.urihttp://hdl.handle.net/2183/24235
dc.description.abstract[Abstract] Three new bismacrocyclic Ln3+ chelates consisting of triamide derivatives of cyclen with glycine, methyl and tert-butyl substituents (L1–3, respectively) linked to an acyclic EGTA-derived calcium chelator were synthesised as potential MRI contrast agents (EGTA – ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid). Eu3+ and Yb3+ complexes of L1–3 were investigated as chemical exchange saturation transfer (CEST) agents. Moderate to minor CEST effects were observed for Eu2L1, Eu2L2 and Yb2L2 complexes in the absence of Ca2+, with negligible changes upon addition of this metal ion. Luminescence steady-state emission and lifetime experiments did not reveal any changes in the coordination environment of the complexes, while the number of inner-sphere water molecules remained constant in the absence and presence of Ca2+. The protonation constants of Eu2L1 and Eu2L2 and stability constants of their complexes with Ca2+, Mg2+ and Zn2+ were determined by means of potentiometric titrations. The results show that the charge of the complex dramatically affects the protonation constants of the EGTA-binding unit. The stability constants of the complexes formed with Ca2+, Mg2+ and Zn2+ are several orders of magnitude lower than those of EGTA. These findings indicate that the nature of Ln3+ chelates and their charge are the main reasons for the observed results and weaker response of these EGTA-derived triamide derivatives compared to their tricarboxylate analogues.es_ES
dc.language.isoenges_ES
dc.publisherRoyal Society of Chemistryes_ES
dc.relation.urihttps://doi.org/10.1039/c5dt04625des_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectContrast agentses_ES
dc.subjectLanthanideses_ES
dc.subjectMacrocycleses_ES
dc.subjectMagnetic resonance imaginges_ES
dc.subjectComplexeses_ES
dc.titleSynthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleDalton Transactionses_ES
UDC.volume45es_ES
UDC.issue15es_ES
UDC.startPage6555es_ES
UDC.endPage6565es_ES


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