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Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agents
dc.contributor.author | Cakic, Nevenka | |
dc.contributor.author | Verbić, Tatjana Ž. | |
dc.contributor.author | Jelić, Ratomir M. | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.contributor.author | Angelovski, Goran | |
dc.date.accessioned | 2019-11-05T11:53:03Z | |
dc.date.available | 2019-11-05T11:53:03Z | |
dc.date.issued | 2016-02-26 | |
dc.identifier.citation | N. Cakić, T. Verbić, R. M. Jelić, C. Platas-Iglesias and G. Angelovski, Dalt. Trans., 2016, 45, 6555–6565. | es_ES |
dc.identifier.issn | 1477-9234 | |
dc.identifier.uri | http://hdl.handle.net/2183/24235 | |
dc.description.abstract | [Abstract] Three new bismacrocyclic Ln3+ chelates consisting of triamide derivatives of cyclen with glycine, methyl and tert-butyl substituents (L1–3, respectively) linked to an acyclic EGTA-derived calcium chelator were synthesised as potential MRI contrast agents (EGTA – ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid). Eu3+ and Yb3+ complexes of L1–3 were investigated as chemical exchange saturation transfer (CEST) agents. Moderate to minor CEST effects were observed for Eu2L1, Eu2L2 and Yb2L2 complexes in the absence of Ca2+, with negligible changes upon addition of this metal ion. Luminescence steady-state emission and lifetime experiments did not reveal any changes in the coordination environment of the complexes, while the number of inner-sphere water molecules remained constant in the absence and presence of Ca2+. The protonation constants of Eu2L1 and Eu2L2 and stability constants of their complexes with Ca2+, Mg2+ and Zn2+ were determined by means of potentiometric titrations. The results show that the charge of the complex dramatically affects the protonation constants of the EGTA-binding unit. The stability constants of the complexes formed with Ca2+, Mg2+ and Zn2+ are several orders of magnitude lower than those of EGTA. These findings indicate that the nature of Ln3+ chelates and their charge are the main reasons for the observed results and weaker response of these EGTA-derived triamide derivatives compared to their tricarboxylate analogues. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation.uri | https://doi.org/10.1039/c5dt04625d | es_ES |
dc.rights | Atribución 3.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Contrast agents | es_ES |
dc.subject | Lanthanides | es_ES |
dc.subject | Macrocycles | es_ES |
dc.subject | Magnetic resonance imaging | es_ES |
dc.subject | Complexes | es_ES |
dc.title | Synthesis and characterisation of bismacrocyclic DO3A-amide derivatives – an approach towards metal-responsive PARACEST agents | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Dalton Transactions | es_ES |
UDC.volume | 45 | es_ES |
UDC.issue | 15 | es_ES |
UDC.startPage | 6555 | es_ES |
UDC.endPage | 6565 | es_ES |
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