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Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial
dc.contributor.author | Garrido-Castells, Xavier | |
dc.contributor.author | Becerro-de-Bengoa-Vallejo, Ricardo | |
dc.contributor.author | Calvo-Lobo, César | |
dc.contributor.author | Losa Iglesias, Marta Elena | |
dc.contributor.author | Palomo-López, Patricia | |
dc.contributor.author | Navarro Flores, Emmanuel | |
dc.contributor.author | López-López, Daniel | |
dc.date.accessioned | 2019-10-03T06:48:23Z | |
dc.date.available | 2019-10-03T06:48:23Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Garrido-Castells, X.; Becerro-de-Bengoa-Vallejo, R.; Calvo-Lobo, C.; Losa-Iglesias, M.E.; Palomo-López, P.; Navarro-Flores, E.; López-López, D. Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial. J. Clin. Med. 2019, 8, 1552. | es_ES |
dc.identifier.issn | 2077-0383 | |
dc.identifier.uri | http://hdl.handle.net/2183/24013 | |
dc.description.abstract | [Abstract] : Background: Leukocyte and platelet-rich fibrin (L-PRF) may be considered a co-adjuvant intervention that may play a key role in blood coagulation and tissue repair after nail surgeries. The aim of this study was to determine the e ectiveness of L-PRF versus nitrofurazone on the post-surgical bleeding and wound cicatrization period in patients with bilateral onychocryptosis during surgeries of chemical matrixectomies with 88% phenol solution. Methods: A randomized single-blind clinical trial was registered with the European Clinical Trials Database (EudraCT) with identification number 2016-002048-18. Twenty healthy participants with bilateral onychocryptosis (n = 40) were recruited and bilaterally received both protocols for both halluces. Patients with a mean age mean of 45.55 12.19 years attended a specialized foot and ankle surgery clinic. Both halluces of each patient were randomized and allocated to receive L-PRF (experimental group; n = 20 halluces) or nitrofurazone (control group; n = 20 halluces) interventions in conjunction with surgery of chemical matrixectomies with 88% phenol solution for bilateral ingrown of toenail border (medial and lateral). Patients were blinded to their intervention in each hallux. The primary outcome measurement was post-surgical bleeding. The secondary outcome measurements were post-surgical pain intensity, inflammation, infection, analgesic intake, and wound cicatrization period. Results: Statistically significant di erences (p < 0.001) were found between both groups showing a reduction for wound cicatrization period and post-surgical bleeding for the L-PRF intervention with respect to nitrofurazone treatment. The rest of the outcome measurements did not show any statistically significant di erences (p > 0.05). Conclusions: L-PRF rather than nitrofurazone in conjunction with chemical matrixectomies performed with 88% phenol solution reduced the wound cicatrization period and bleeding after nail surgery. Thus, L-PRF may be considered a first-line co-adjuvant intervention for patients who su er from nail problems, such as onychocryptosis, that require surgical procedures | es_ES |
dc.language.iso | eng | es_ES |
dc.relation.uri | https://www.mdpi.com/2077-0383/8/10/1552 | es_ES |
dc.rights | Atribución 4.0 España | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.subject | Inflammation | es_ES |
dc.subject | Nail diseases | es_ES |
dc.subject | Pain | es_ES |
dc.subject | Platelet rich plasma | es_ES |
dc.subject | Surgery | es_ES |
dc.title | Effectiveness of Leukocyte and Platelet-Rich Fibrin versus Nitrofurazone on Nail Post-Surgery Bleeding and Wound Cicatrization Period Reductions: A Randomized Single Blinded Clinical Trial | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Journal of Clinical Medicine | es_ES |
UDC.volume | 8 | es_ES |
UDC.startPage | 1552 | es_ES |
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