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dc.contributor.authorAnguiano, Lidia
dc.contributor.authorRiera, Marta
dc.contributor.authorPascual, Julio
dc.contributor.authorValdivielso, José Manuel
dc.contributor.authorBarrios, Clara
dc.contributor.authorBetriu, Angels
dc.contributor.authorMojal, Sergi
dc.contributor.authorFernández, Elvira
dc.contributor.authorSoler, María José
dc.contributor.authorPérez-Fontán, Miguel
dc.date.accessioned2018-12-17T13:03:26Z
dc.date.available2018-12-17T13:03:26Z
dc.date.issued2015-03-26
dc.identifier.citationAnguiano L, Riera M, Pascual J, Valdivielso JM, Barrios C, Betriu A, Mojal S, Fernández E, Soler MJ; NEFRONA study. Circulating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular disease. Nephrol Dial Transplant. 2015 Jul;30(7):1176-85.es_ES
dc.identifier.issn0931-0509
dc.identifier.urihttp://hdl.handle.net/2183/21525
dc.description.abstract[Abstract] Background. Patients with cardiovascular (CV) disease have an increased circulating angiotensin-converting enzyme 2 (ACE2) activity, but there is little information about changes in ACE2 in chronic kidney disease (CKD) patients without history of CV disease. We examined circulating ACE2 activity in CKD patients at stages 3–5 (CKD3-5) and in dialysis (CKD5D) without any history of CV disease. Methods. Circulating ACE2 activity was measured in human ethylenediamine-tetraacetic acid (EDTA)-plasma samples from the NEFRONA study (n = 2572): control group (CONT) (n = 568), CKD3-5 (n = 1458) and CKD5D (n = 546). Different clinical and analytical variables such as gender; age; history of diabetes mellitus (DM), dyslipidemia and hypertension; glycaemic, renal, lipid and anaemia profiles; vitamin D analogues treatment and antihypertensive treatments (angiotensin-converting enzyme inhibitor and angiotensin receptor blockade) were analysed. Circulating ACE2 and ACE activities were measured using modified fluorimetric assay for EDTA-plasma samples, where zinc chloride was added to recover enzymatic activity. Results. In CKD3-5 and CKD5D, significant decrease in circulating ACE2 activity was observed when compared with CONT, but no differences were found between CKD3-5 and CKD5 when performing paired case-control studies. By multivariate linear regression analysis, male gender and advanced age were identified as independent predictors of ACE2 activity in all groups. Diabetes was identified as independent predictor of ACE2 activity in CKD3-5. Significant increase in the activity of circulating ACE was found in CKD3-5 and CKD5D when compared with CONT and in CKD5D when compared with CKD3-5. By multiple regression analysis, female gender and younger age were identified as independent predictors of ACE activity in CONT and CKD3-5. Diabetes was also identified as an independent predictor of ACE activity in CKD3-5 patients. Conclusions. Circulating ACE2 and ACE activities can be measured in human EDTA-plasma samples with zinc added to recover enzymatic activity. In a CKD population without previous history of CV disease, ACE2 activity from human EDTA-plasma samples directly correlated with the classical CV risk factors namely older age, diabetes and male gender. Our data suggest that circulating ACE2 is altered in CKD patients at risk for CV event.es_ES
dc.description.sponsorshipThis work was made with funding from the projects ISCIII-FEDER. PI 11/01549 and ISCIII-RETIC REDinREN RD12/0021/0024.
dc.description.sponsorshipinfo:eu-repo/grantAgreement/MICINN/Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia/PI11%2F01549/ES/Actividad sérica del ECA2 en pacientes diabéticos con Enfermedad Renal Crónica. Efecto de la deleción del ECA2 en la nefropatía diabética experimental
dc.description.sponsorshipInstituto de Salud Carlos III; RD12/0021/0024
dc.language.isoenges_ES
dc.publisherOxfordes_ES
dc.relation.urihttps://doi.org/10.1093/ndt/gfv025es_ES
dc.rightsThis is a pre-copyedited, author-produced version of the article accepted for publication in Nephrology Dialysis Transplantation following peer review. The version of recors is avaliable online at Oxford Academic web page.es_ES
dc.subjectACE2es_ES
dc.subjectBiomarkeres_ES
dc.subjectCardiovascular diseaseses_ES
dc.subjectChronic kidney diseasees_ES
dc.subjectDiabeteses_ES
dc.subjectRenin-angiotensin systemes_ES
dc.titleCirculating angiotensin-converting enzyme 2 activity in patients with chronic kidney disease without previous history of cardiovascular diseasees_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleNephrology Dialysis Transplantationes_ES
UDC.volume30es_ES
UDC.issue7es_ES
UDC.startPage1176es_ES
UDC.endPage1185es_ES


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