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PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine: an overview
dc.contributor.author | Rey-Rico, Ana | |
dc.contributor.author | Cucchiarini, Magali | |
dc.date.accessioned | 2018-06-18T07:06:37Z | |
dc.date.available | 2018-06-18T07:06:37Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Rey-Rico, Ana, Cucchiarini, Magali. PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine: an overview. International Journal of Molecular Sciences. 2018,19,775. | es_ES |
dc.identifier.issn | 1422-0067 | |
dc.identifier.uri | http://hdl.handle.net/2183/20814 | |
dc.description.abstract | [Abstract:] Lineal (poloxamers or Pluronic®) or X-shaped (poloxamines or Tetronic®) amphiphilic tri-block copolymers of poly(ethylene oxide) and poly(propylene oxide) (PEO-PPO-PEO) have been broadly explored for controlled drug delivery in different regenerative medicine approaches. The ability of these copolymers to self-assemble as micelles and to undergo sol-to-gel transitions upon heating has endowed the denomination of “smart” or “intelligent” systems. The use of PEO-PPO-PEO copolymers as gene delivery systems is a powerful emerging strategy to improve the performance of classical gene transfer vectors. This review summarizes the state of art of the application of PEO-PPO-PEO copolymers in both nonviral and viral gene transfer approaches and their potential as gene delivery systems in different regenerative medicine approaches. | es_ES |
dc.language.iso | eng | es_ES |
dc.rights | Atribución 3.0 España | |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | |
dc.subject | PEO-PPO-PEO copolymers | es_ES |
dc.subject | Nonviral vectors | es_ES |
dc.subject | Viral vectors | es_ES |
dc.subject | Gene transfer | es_ES |
dc.title | PEO-PPO-PEO Tri-Block Copolymers for Gene Delivery Applications in Human Regenerative Medicine: an overview | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | |
UDC.journalTitle | International Journal of Molecular Sciences | es_ES |
UDC.volume | 19 | es_ES |
dc.identifier.doi | doi:10.3390/ijms19030775 |
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