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dc.contributor.authorMebazaa, Alexandre
dc.contributor.authorMotiejunaite, Justina
dc.contributor.authorGayat, Etienne
dc.contributor.authorCrespo-Leiro, María Generosa
dc.contributor.authorLund, Lars H.
dc.contributor.authorMaggioni, Aldo P.
dc.contributor.authorChioncel, Ovidiu
dc.contributor.authorAkiyama, Eiichi
dc.contributor.authorHarjola, Veli-Pekka
dc.contributor.authorSeferovic, Petar M.
dc.contributor.authorLaroche, Cécile
dc.contributor.authorSanz Julve, Marisa
dc.contributor.authorRoig, Eulàlia
dc.contributor.authorRuschitzka, Frank
dc.contributor.authorFilippatos, Gerasimos
dc.date.accessioned2018-04-30T11:37:32Z
dc.date.issued2017-10-08
dc.identifier.citationMebazaa A, Motiejunaite J, Gayat E, Crespo-Leiro MG, Lund LH, Maggioni AP, et al. Long‐term safety of intravenous cardiovascular agents in acute heart failure: results from the European Society of Cardiology Heart Failure Long‐Term Registry. Eur J Heart Fail. 2018;20(2):332-341es_ES
dc.identifier.issn1388-9842
dc.identifier.urihttp://hdl.handle.net/2183/20651
dc.description.abstract[Abstract] Aims. The aim of this study was to assess long‐term safety of intravenous cardiovascular agents—vasodilators, inotropes and/or vasopressors—in acute heart failure (AHF). Methods and results. The European Society of Cardiology Heart Failure Long‐Term (ESC‐HF‐LT) registry was a prospective, observational registry conducted in 21 countries. Patients with unscheduled hospitalizations for AHF (n = 6926) were included: 1304 (18.8%) patients received a combination of intravenous (i.v.) vasodilators and diuretics, 833 (12%) patients received i.v. inotropes and/or vasopressors. Primary endpoint was long‐term all‐cause mortality. Main secondary endpoints were in‐hospital and post‐discharge mortality. Adjusted hazard ratio (HR) showed no association between the use of i.v. vasodilator and diuretic and long‐term mortality [HR 0.784, 95% confidence interval (CI) 0.596–1.032] nor in‐hospital mortality (HR 1.049, 95% CI 0.592–1.857) in the matched cohort (n = 976 paired patients). By contrast, adjusted HR demonstrated a detrimental association between the use of i.v. inotrope and/or vasopressor and long‐term all‐cause mortality (HR 1.434, 95% CI 1.128–1.823), as well as in‐hospital mortality (HR 1.873, 95% CI 1.151–3.048) in the matched cohort (n = 606 paired patients). No association was found between the use of i.v. inotropes and/or vasopressors and long‐term mortality in patients discharged alive (HR 1.078, 95% CI 0.769–1.512). A detrimental association with inotropes and/or vasopressors was seen in all geographic regions and, among catecholamines, dopamine was associated with the highest risk of death (HR 1.628, 95% CI 1.031–2.572 vs. no inotropes). Conclusions. Vasodilators did not demonstrate any association with long‐term clinical outcomes, while inotropes and/or vasopressors were associated with increased risk of all‐cause death, mostly related to excess of in‐hospital mortality in AHF.es_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.urihttp://dx.doi.org/10.1002/ejhf.991es_ES
dc.rightsThis is the peer reviewed version of the article which has been published in final form at Wiley Online Library. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for self-archiving.es_ES
dc.subjectAcute heart failurees_ES
dc.subjectInotropees_ES
dc.subjectVasopressores_ES
dc.subjectVasodilatores_ES
dc.subjectPrognosises_ES
dc.subjectLong-term outcomees_ES
dc.titleLong‐term safety of intravenous cardiovascular agents in acute heart failure: results from the European Society of Cardiology Heart Failure Long‐Term Registryes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/embargoedAccesses_ES
dc.date.embargoEndDate2018-10-08es_ES
dc.date.embargoLift2018-10-08
UDC.journalTitleEuropean Journal of Heart Failurees_ES
UDC.volume20es_ES
UDC.issue2es_ES
UDC.startPage332es_ES
UDC.endPage341es_ES


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