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dc.contributor.authorMedina Villaamil, Vanessa
dc.contributor.authorAparicio Gallego, Guadalupe
dc.contributor.authorValbuena Ruvira, L.
dc.contributor.authorGarcía Campelo, R.
dc.contributor.authorValladares-Ayerbes, Manuel
dc.contributor.authorGrande Pulido, Enrique
dc.contributor.authorBolós Fernández, Victoria
dc.contributor.authorSantamarina, Isabel
dc.contributor.authorAntón-Aparicio, Luis M.
dc.date.accessioned2018-04-24T09:58:24Z
dc.date.available2018-04-24T09:58:24Z
dc.date.issued2010-12-10
dc.identifier.citationMedina Villaamil V, Aparicio Gallego G, Valbuena Rubira L, García Campelo R, Valladares-Ayerbes M, Grande Pulido E, et al. Fructose transporter Glut5 expression in clear renal cell carcinoma. Oncol Rep. 2011;25(2):315-323es_ES
dc.identifier.issn1021-335X
dc.identifier.issn1791-2431
dc.identifier.urihttp://hdl.handle.net/2183/20620
dc.description.abstract[Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous tubular and spindle cell and associated with Xp 11.2 translocations/TFE 3 gene fusion, are much less common. There is also a residual group of unclassified cases. Previous studies have shown that RCC has high glycolytic rates, and expresses GLUT transporters, but no distinction has been made among the different subtypes of renal cell tumours and their grades of malignancy. In clear renal cell carcinoma (cRCC) glycogen levels increase, glycolysis is activated and gluconeogenesis is reduced. The clear cell subtype of RCC is characterized histologically by a distinctive pale, glassy cytoplasm and this appearance of cRCC is due to abnormalities in carbohydrate and lipid metabolism, and this abnormality results in glycogen and sterol storage. Several isoforms of glucose carriers (GLUTs) have been identified. We show here in a panel of 80 cRCC samples a significant correlation between isoform 5 (GLUT5) and many pathological parameters such as grade of differentiation, pelvis invasion and breaking capsule. GLUT5 expression also appears to associate more strongly with the clear cell RCC subtype. These data suggest a role for the GLUT5 isoform in fructose uptake that takes place in cRCC cells and which subsequently leads to the malignant RCC progression.es_ES
dc.language.isoenges_ES
dc.publisherSpandidoses_ES
dc.relation.urihttp://dx.doi.org/10.3892/or.2010.1096es_ES
dc.subjectClear renal cell carcinomaes_ES
dc.subjectExpressiones_ES
dc.subjectGLUT5es_ES
dc.titleFructose transporter Glut5 expression in clear renal cell carcinomaes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleOncology Reportses_ES
UDC.volume25es_ES
UDC.issue2es_ES
UDC.startPage315es_ES
UDC.endPage323es_ES


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