Mostrar o rexistro simple do ítem
Developing the family of picolinate ligands for Mn2+ complexation
dc.contributor.author | Forgács, Attila | |
dc.contributor.author | Pujales-Paradela, Rosa | |
dc.contributor.author | Regueiro-Figueroa, Martín | |
dc.contributor.author | Valencia, Laura | |
dc.contributor.author | Esteban-Gómez, David | |
dc.contributor.author | Botta, Mauro | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.date.accessioned | 2017-10-31T14:38:06Z | |
dc.date.available | 2017-10-31T14:38:06Z | |
dc.date.issued | 2016-12-22 | |
dc.identifier.citation | Developing the family of picolinate ligands for Mn2+ complexation. A. Forgács, R. Pujales-Paradela, M. Regueiro-Figueroa, L. Valencia, D. Esteban-Gómez, M. Botta and C. Platas-Iglesias, Dalt. Trans., 2017, 46, 1546–1558. | es_ES |
dc.identifier.issn | 1477-9226 | |
dc.identifier.issn | 1477-9234 | |
dc.identifier.uri | http://hdl.handle.net/2183/19672 | |
dc.description.abstract | [Abstract] We have reported here a series of ligands containing pentadentate 6,6′-(azanediylbis(methylene))dipicolinic acid units that differ in the substituent present at the amine nitrogen atom (acetate: H3DPAAA; phenyl: H2DPAPhA; dodecyl: H2DPAC12A; 4-hexylphenyl: H2DPAC6PhA). The protonation constants of the hexadentate DPAAA3− and pentadentate DPAPhA2−ligands and the stability constants of their Mn2+ complexes were determined using pH-potentiometry (25 °C, 0.15 M NaCl). The mono-hydrated [Mn(DPAAA)]− complex (logKMnL = 13.19(5)) was found to be considerably more stable than the bis-hydrated [Mn(DPAPhA)] analogue (logKMnL = 9.55(1)). A detailed 1H and 17O NMR relaxometric study was carried out to determine the parameters that govern the proton relaxivities of these complexes. The [Mn(DPAC12A)] complex, which contains a dodecyl lipophilic chain, forms micelles in solution characterized by a critical micellar concentration (cmc) of 96(9) μM. The lipophilic [Mn(DPAC6PhA)] and [Mn(DPAC12A)] derivatives form rather strong adducts with Human Serum Albumin (HSA) with association constants of 7.1 ± 0.1 × 103 and 1.3 ± 0.4 × 105 M−1, respectively. The X-ray structure of the complex {K(H2O)4}{[Mn(DPAAA)(H2O)]}2 shows that the Mn2+ ion in [Mn(DPAAA)]− is coordinated to the six donor atoms of the ligand, a coordinated water molecule completing the pentagonal bipyramidal coordination environment. | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad; CTQ2015-71211-REDT | es_ES |
dc.description.sponsorship | Ministerio de Economía y Competitividad; CTQ2016-76756-P | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society of Chemistry | es_ES |
dc.relation.uri | https://doi.org/10.1039/C6DT04442E | es_ES |
dc.subject | Magnetic resonance imaging | es_ES |
dc.subject | Manganese complexes | es_ES |
dc.subject | Picolinate ligands | es_ES |
dc.subject | Relaxivity | es_ES |
dc.subject | DFT calculations | es_ES |
dc.title | Developing the family of picolinate ligands for Mn2+ complexation | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
dc.date.embargoEndDate | 2017-12-23 | |
dc.date.embargoLift | 2017-12-23 | |
UDC.journalTitle | Dalton Transactions | es_ES |
UDC.volume | 46 | es_ES |
UDC.issue | 5 | es_ES |
UDC.startPage | 1546 | es_ES |
UDC.endPage | 1558 | es_ES |
Ficheiros no ítem
Este ítem aparece na(s) seguinte(s) colección(s)
-
GI-REACT! - Artigos [107]