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Approaching the kinetic inertness of macrocyclic gadolinium(III)-based MRI contrast agents with highly rigid open-chain derivatives
dc.contributor.author | Tircsó, Gyula | |
dc.contributor.author | Regueiro-Figueroa, Martín | |
dc.contributor.author | Nagy, Viktória | |
dc.contributor.author | Garda, Zoltán | |
dc.contributor.author | Garai, Tamás | |
dc.contributor.author | Kálmán, Ferenc | |
dc.contributor.author | Esteban-Gómez, David | |
dc.contributor.author | Tóth, Éva | |
dc.contributor.author | Platas-Iglesias, Carlos | |
dc.date.accessioned | 2017-10-30T14:10:56Z | |
dc.date.available | 2017-10-30T14:10:56Z | |
dc.date.issued | 2016-01-08 | |
dc.identifier.citation | Tircsó, G., Regueiro-Figueroa, M., Nagy, V., Garda, Z., Garai, T., Kálmán, F. K., Esteban-Gómez, D., Tóth, E. and Platas-Iglesias, C. (2016), Approaching the kinetic inertness of macrocyclic gadolinium(III)-based MRI contrast agents with highly rigid open-chain derivatives. Chem. Eur. J., 22: 896-901. | es_ES |
dc.identifier.issn | 0947-6539 | |
dc.identifier.issn | 1521-3765 | |
dc.identifier.uri | http://hdl.handle.net/2183/19665 | |
dc.description.abstract | [Abstract] A highly rigid open-chain octadentate ligand (H4cddadpa) containing a diaminocylohexane unit to replace the ethylenediamine bridge of 6,6′-[(ethane-1,2 diylbis{(carboxymethyl)azanediyl})bis(methylene)] dipicolinic acid (H4octapa) was synthesized. This structural modification improves the thermodynamic stability of the Gd3+ complex slightly (log KGdL=20.68 vs. 20.23 for [Gd(octapa)]−) while other MRI-relevant parameters remain unaffected (one coordinated water molecule; relaxivity r1=5.73 mm−1 s−1 at 20 MHz and 295 K). Kinetic inertness is improved by the rigidifying effect of the diaminocylohexane unit in the ligand skeleton (half-life of dissociation for physiological conditions is 6 orders of magnitude higher for [Gd(cddadpa)]− (t1/2=1.49×105 h) than for [Gd(octapa)]−. The kinetic inertness of this novel chelate is superior by 2–3 orders of magnitude compared to non-macrocyclic MRI contrast agents approved for clinical use. | es_ES |
dc.description.sponsorship | Hungarian Scientific Research Fund. OTKA; K-84291 | es_ES |
dc.description.sponsorship | Hungarian Scientific Research Fund. OTKA; K-109029 | es_ES |
dc.description.sponsorship | European Commission; TÁMOP-4.2.2A-11/1/KONV-2012-0043 | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley | es_ES |
dc.relation.uri | https://doi.org/10.1002/chem.201503836 | es_ES |
dc.rights | This is the peer reviewed version of the following article: Tircsó, G., Regueiro-Figueroa, M., Nagy, V., Garda, Z., Garai, T., Kálmán, F. K., Esteban-Gómez, D., Tóth, E. and Platas-Iglesias, C. (2016), Approaching the kinetic inertness of macrocyclic gadolinium(III)-based MRI contrast agents with highly rigid open-chain derivatives. Chem. Eur. J., 22: 896-901, which has been published in final form at https://doi.org/10.1002/chem.201503836. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | es_ES |
dc.subject | Contrast agents | es_ES |
dc.subject | Coordination compounds | es_ES |
dc.subject | Gadolinium | es_ES |
dc.subject | Lanthanides | es_ES |
dc.subject | NMR imaging | es_ES |
dc.title | Approaching the kinetic inertness of macrocyclic gadolinium(III)-based MRI contrast agents with highly rigid open-chain derivatives | es_ES |
dc.type | info:eu-repo/semantics/article | es_ES |
dc.rights.access | info:eu-repo/semantics/openAccess | es_ES |
UDC.journalTitle | Chemistry - A European Journal | es_ES |
UDC.volume | 22 | es_ES |
UDC.issue | 3 | es_ES |
UDC.startPage | 896 | es_ES |
UDC.endPage | 901 | es_ES |
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