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dc.contributor.authorElhabiri, Mourad
dc.contributor.authorAbada, Sabah
dc.contributor.authorSy, Mohamadou
dc.contributor.authorNonat, Aline
dc.contributor.authorChoquet, Philippe
dc.contributor.authorEsteban-Gómez, David
dc.contributor.authorCassino, Claudio
dc.contributor.authorPlatas-Iglesias, Carlos
dc.contributor.authorBotta, Mauro
dc.contributor.authorCharbonnière, Loïc J.
dc.date.accessioned2017-10-27T13:34:23Z
dc.date.available2017-10-27T13:34:23Z
dc.date.issued2015-04-10
dc.identifier.citationElhabiri, M., Abada, S., Sy, M., Nonat, A., Choquet, P., Esteban-Gómez, D., Cassino, C., Platas-Iglesias, C., Botta, M. and Charbonnière, L. J. (2015), Importance of outer-sphere and aggregation phenomena in the relaxation properties of phosphonated gadolinium complexes with potential applications as MRI contrast agents. Chem. Eur. J., 21: 6535–6546.es_ES
dc.identifier.issn0947-6539
dc.identifier.issn1521-3765
dc.identifier.urihttp://hdl.handle.net/2183/19649
dc.description.abstract[Abstract] A series composed of a tetra-, a tris- and a bisphosphonated ligand based on a pyridine scaffold (L4, L3 and L2, respectively) was studied within the frame of lanthanide (Ln) coordination. The stability constants of the complexes formed with lanthanide cations (Ln=La, Nd, Eu, Gd, Tb, Er and Lu) were determined by potentiometry in aqueous solutions (25.0 °C, 0.1 M NaClO4), showing that the tetraphosphonated complexes are among the most stable LnIII complexes reported in the literature. The complexation of L4 was further studied by different titration experiments using mass spectrometry and various spectroscopic techniques including UV/Vis absorption, and steady state and time-resolved luminescence (Ln=Eu and Tb). Titration experiments confirmed the formation of highly stable [LnL4] complexes. 31P NMR experiments of the LuL4 complex revealed an intramolecular interconversion process which was studied at different temperatures and was rationalized by DFT modelling. The relaxivity properties of the GdIII complexes were studied by recording their 1H NMRD profiles at various temperatures, by temperature dependent 17O NMR experiments (GdL4) and by pH dependent relaxivity measurements at 0.47 T (GdL3 and GdL2). In addition to the high relaxivity values observed for all complexes, the results showed an important second-sphere contribution to relaxivity and pH dependent variations associated with the formation of aggregates for GdL2 and GdL3. Finally, intravenous injection of GdL4 to a mouse was followed by dynamic MRI imaging at 1.5 T, which showed that the complex can be immediately found in the blood stream and rapidly eliminated through the liver and in large part through the kidneys.es_ES
dc.description.sponsorshipTorino. Compagnia di San Paolo; CSP-2012 NANOPROGLYes_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.urihttps://doi.org/10.1002/chem.201500155es_ES
dc.rightsThis is the peer reviewed version of the following article: Elhabiri, M., Abada, S., Sy, M., Nonat, A., Choquet, P., Esteban-Gómez, D., Cassino, C., Platas-Iglesias, C., Botta, M. and Charbonnière, L. J. (2015), Importance of outer-sphere and aggregation phenomena in the relaxation properties of phosphonated gadolinium complexes with potential applications as MRI contrast agents. Chem. Eur. J., 21: 6535–6546, which has been published in final form at https://doi.org/10.1002/chem.201500155. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.es_ES
dc.subjectImaging agentses_ES
dc.subjectLanthanideses_ES
dc.subjectLuminescencees_ES
dc.subjectPhosphonatees_ES
dc.subjectRelaxivityes_ES
dc.titleImportance of outer-sphere and aggregation phenomena in the relaxation properties of phosphonated gadolinium complexes with potential applications as MRI contrast agentses_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleChemistry - A European Journales_ES
UDC.volume21es_ES
UDC.issue17es_ES
UDC.startPage6535es_ES
UDC.endPage6546es_ES


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