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dc.contributor.authorBurgeiro, Ana
dc.contributor.authorCerqueira, Manuela G.
dc.contributor.authorVarela-Rodríguez, Bárbara María
dc.contributor.authorNunes, Sara
dc.contributor.authorNeto, Paula
dc.contributor.authorPereira, Frederico C.
dc.contributor.authorReis, Flávio
dc.contributor.authorCarvalho, Eugénia
dc.date.accessioned2017-10-27T09:26:29Z
dc.date.available2017-10-27T09:26:29Z
dc.date.issued2017-06-21
dc.identifier.citationBurgeiro, A.; Cerqueira, M.G.; Varela-Rodríguez, B.M.; Nunes, S.; Neto, P.; Pereira, F.C.; Reis, F.; Carvalho, E. Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients 2017, 9, 638.es_ES
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/2183/19643
dc.description.abstract[Abstract] Glucotoxicity and lipotoxicity are key features of type 2 diabetes mellitus, but their molecular nature during the early stages of the disease remains to be elucidated. We aimed to characterize glucose and lipid metabolism in insulin-target organs (liver, skeletal muscle, and white adipose tissue) in a rat model treated with a high-sucrose (HSu) diet. Two groups of 16-week-old male Wistar rats underwent a 9-week protocol: HSu diet (n = 10)—received 35% of sucrose in drinking water; Control (n = 12)—received vehicle (water). Body weight, food, and beverage consumption were monitored and glucose, insulin, and lipid profiles were measured. Serum and liver triglyceride concentrations, as well as the expression of genes and proteins involved in lipid biosynthesis were assessed. The insulin-stimulated glucose uptake and isoproterenol-stimulated lipolysis were also measured in freshly isolated adipocytes. Even in the absence of obesity, this rat model already presented the main features of prediabetes, with fasting normoglycemia but reduced glucose tolerance, postprandial hyperglycemia, compensatory hyperinsulinemia, as well as decreased insulin sensitivity (resistance) and hypertriglyceridemia. In addition, impaired hepatic function, including altered gluconeogenic and lipogenic pathways, as well as increased expression of acetyl-coenzyme A carboxylase 1 and fatty acid synthase in the liver, were observed, suggesting that liver glucose and lipid dysmetabolism may play a major role at this stage of the disease.es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; FCT; EXCL/DTP-PIC/0069/2012es_ES
dc.description.sponsorshipPortugal. Fundação para a Ciência e a Tecnologia; FCT; UID/NEU/04539/2013es_ES
dc.description.sponsorshipEuropean Commision; FCOMP-01-0124-FEDER-028417es_ES
dc.description.sponsorshipEuropean Commision; POCI-01-0145-FEDER-007440es_ES
dc.description.sponsorshipEuropean Commision; CENTRO-01-0145-FEDER-000012es_ES
dc.description.sponsorshipEuropean Commision; CENTRO-01-0145-FEDER-000008es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Dixital Publishing Institutees_ES
dc.relation.urihttps://doi.org/10.3390/nu9060638es_ES
dc.rightsAtribución 3.0 Españaes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectHigh-sucrose dietes_ES
dc.subjectPrediabeteses_ES
dc.subjectGlucosees_ES
dc.subjectLipides_ES
dc.subjectMetabolismes_ES
dc.subjectHypertriglyceridemiaes_ES
dc.titleGlucose and lipid dysmetabolism in a rat model of prediabetes induced by a high-sucrose dietes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/openAccesses_ES
UDC.journalTitleNutrientses_ES
UDC.volume9es_ES
UDC.issue6es_ES
UDC.startPage638es_ES


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