A semantic interoperability approach to support integration of gene expression and clinical data in breast cancer
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http://hdl.handle.net/2183/19361
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A semantic interoperability approach to support integration of gene expression and clinical data in breast cancerAuthor(s)
Date
2017-06-05Citation
Alonso-Calvo R, Paraíso-Medina S, Pérez-Rey D, Alonso-Oset E, Stiphout R, Yu S, et al. A semantic interoperability approach to support integration of gene expression and clinical data in breast cancer. Comput Biol Med. 2017;87:179-186
Abstract
[Abstract] Introduction. The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient stratification across health institutions due to omic profiling presents a complex scenario to carry out multi-center clinical trials.
Methods. This paper presents a standards-based approach to ensure semantic integration required to facilitate the analysis of clinico-genomic clinical trials. To ensure interoperability across different institutions, we have developed a Semantic Interoperability Layer (SIL) to facilitate homogeneous access to clinical and genetic information, based on different well-established biomedical standards and following International Health (IHE) recommendations.
Results. The SIL has shown suitability for integrating biomedical knowledge and technologies to match the latest clinical advances in healthcare and the use of genomic information. This genomic data integration in the SIL has been tested with a diagnostic classifier tool that takes advantage of harmonized multi-center clinico-genomic data for training statistical predictive models.
Conclusions. The SIL has been adopted in national and international research initiatives, such as the EURECA-EU research project and the CIMED collaborative Spanish project, where the proposed solution has been applied and evaluated by clinical experts focused on clinico-genomic studies.
Keywords
Clinical research informatics
Semantic interoperability
Data integration
Diagnostic classifier
Gene expression
Biomedical terminologies
Semantic interoperability
Data integration
Diagnostic classifier
Gene expression
Biomedical terminologies
Editor version
Rights
Atribución-NoComercial-SinDerivadas 3.0 España
ISSN
0010-4825
1879-0534
1879-0534