Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates
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Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine InvertebratesData
2013Cita bibliográfica
Marine Drugs 2013, Vol. 11, Pages 2829-2845
Resumo
Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination in the oceans, producing high concentrations of potentially harmful biotoxins that are accumulated across the food chains. One such biotoxin, Okadaic Acid (OA), is produced by marine dinoflagellates and subsequently accumulated within the tissues of filtering marine organisms feeding on HABs, rapidly spreading to their predators in the food chain and eventually reaching human consumers causing Diarrhetic Shellfish Poisoning (DSP) syndrome. While numerous studies have thoroughly evaluated the effects of OA in mammals, the attention drawn to marine organisms in this regard has been scarce, even though they constitute primary targets for this biotoxin. With this in mind, the present work aimed to provide a timely and comprehensive insight into the current literature on the effect of OA in marine invertebrates, along with the strategies developed by these organisms to respond to its toxic effect together with the most important methods and techniques used for OA detection and evaluation.
Palabras chave
Biotoxins
Accumulation
Depuration
Food chain
Diarrhetic shellfish poisoning
Tumor
Apoptosis
Genome integrity
Accumulation
Depuration
Food chain
Diarrhetic shellfish poisoning
Tumor
Apoptosis
Genome integrity
Versión do editor
Dereitos
Reconocimiento 3.0
ISSN
1660-3397