ListarGrupos de investigación por tema "Mitochondria"

Mostrando ítems 1-10 de 10

    • An atlas of the knee joint proteins and their role in osteoarthritis defined by literature mining 

      Paz-González, Rocío; Lourido, Lucía; Calamia, Valentina; Fernández-Puente, Patricia; Quaranta, Patricia; Picchi, Florencia; Blanco García, Francico J; Ruiz-Romero, Cristina (Elsevier, 2023-08)
      [Abstract] Osteoarthritis (OA) is the most prevalent rheumatic pathology. However, OA is not simply a process of wear and tear affecting articular cartilage but rather a disease of the entire joint. One of the most common ...

    • Beneficial effects of bariatric surgery-induced by weight loss on the proteome of abdominal subcutaneous adipose tissue 

      Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Varela, Luis; Outeiriño-Blanco, Elena; García-Brao, María Jesús; Mena, Enrique; Noguera, José Francisco; Valero-Gasalla, Javier; Cordido, Fernando; Sangiao-Alvarellos, Susana; Bravo, Susana Belén (MDPI, 2020-01-13)
      [Abstract] Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from ...

    • FASN activity is important for the initial stages of the induction of senescence 

      Fafián Labora, Juan Antonio; Carpintero-Fernández, Paula; Jordan, Samuel James Davison; Shikh-Bahaei, Tamanna; Abdullah, Sana Mohammad; Mahenthiran, Midusa; Rodríguez-Navarro, José Antonio; Niklison-Chirou, María Victoria; O’Loghlen, Ana (Springer Nature, 2019-04-08)
      [Abstract] Senescent cells accumulate in several tissues during ageing and contribute to several pathological processes such as ageing and cancer. Senescence induction is a complex process not well defined yet and is ...

    • Hydrogen sulfide and inflammatory joint diseases 

      Burguera, Elena F.; Meijide-Faílde, Rosa; Blanco García, Francisco J (Bentham, 2017)
      [Abstract] Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are widespread rheumatic diseases characterized by persistent inflammation and joint destruction. Hydrogen sulfide (H2S) is an endogenous gas with ...

    • Involvement of mitochondrial dysfunction in the inflammatory response in human mesothelial cells from peritoneal dialysis effluent 

      Ramil-Gómez, Olalla; López-Pardo, Mirian; Fernández-Rodríguez, Jennifer Adriana; Rodríguez-Carmona, Ana; Pérez-López, Teresa; Vaamonde-García, Carlos; Pérez-Fontán, Miguel; López-Armada, María José (MDPI, 2022-11-04)
      [Abstract] Recent studies have related mitochondrial impairment with peritoneal membrane damage during peritoneal dialysis (PD) therapy. Here, we assessed the involvement of mitochondrial dysfunction in the inflammatory ...

    • Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells 

      López-Armada, María José; Caramés, Beatriz; Martín, M.A.; Cillero-Pastor, B.; Lires-Dean, M.; Fuentes Boquete, Isaac Manuel; Arenas, J.; Blanco García, Francisco J (Elsevier, 2006-05-05)
      [Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ...

    • Mitochondrial dysfunction and oxidative stress in rheumatoid arthritis 

      López-Armada, María José; Fernández-Rodríguez, Jennifer Adriana; Blanco García, Francisco J (MDPI, 2022-06-12)
      [Abstract] Control of excessive mitochondrial oxidative stress could provide new targets for both preventive and therapeutic interventions in the treatment of chronic inflammation or any pathology that develops under an ...

    • Mitochondrial genetics and epigenetics in osteoarthritis 

      Rego-Pérez, Ignacio; Durán-Sotuela, Alejandro; Ramos-Louro, Paula; Blanco García, Francisco J (Frontiers, 2020-01-17)
      [Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ...

    • Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes 

      Vázquez-Mosquera, María E.; Fernández-Moreno, Mercedes; Cortés-Pereira, Estefanía; Relaño, Sara; Dalmao-Fernández, Andrea; Ramos-Louro, Paula; Durán Sotuela, Alejandro; Rego-Pérez, Ignacio; Blanco García, Francisco J (Frontiers, 2021-06-15)
      [Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors ...

    • The mitochondrial inhibitor oligomycin induces an inflammatory response in the rat knee joint 

      Vaamonde-García, Carlos; Loureiro, Jesús; Valcárcel Ares, Marta Noa; Riveiro Naveira, Romina R.; Ramil-Gómez, Olalla; Hermida-Carballo, Laura; Centeno, Alberto; Meijide-Faílde, Rosa; Blanco García, Francisco J; López-Armada, María José (BioMed Central, 2017-06-12)
      [Abstract] Background. Recent findings support a connection between mitochondrial dysfunction and activation of inflammatory pathways in articular cells. This study investigates in vivo in an acute model whether ...