Listar Grupos de investigación por autor "Venkatesan, Jagadeesh Kumar"
Mostrando ítems 1-10 de 10
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Biomaterial-Assisted Gene Therapy for Translational Approaches to Treat Musculoskeletal Disorders
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Cai, Xiaoyu; Pons, Françoise; Lebeau, Luc; Migonney, Véronique; Madry, Henning; Cucchiarini, Magali (Elsevier, 2020-12-28)[Abstract] Biomaterial-assisted gene therapy is a promising strategy for the treatment of various musculoskeletal disorders such as those concerning the articular cartilage, bones, tendons and ligaments, and meniscus as ... -
Current trends in viral gene therapy for human orthopaedic regenerative medicine
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Cucchiarini, Magali (Springer, 2019-02-21)[Abstract] Background: Viral vector-based therapeutic gene therapy is a potent strategy to enhance the intrinsic reparative abilities of human orthopaedic tissues. However, clinical application of viral gene transfer remains ... -
Effects of rAAV-Mediated sox9 Overexpression on the Biological Activities of Human Osteoarthritic Articular Chondrocytes in Their Intrinsic Three-Dimensional Environment
Daniels, Oliver; Rey-Rico, Ana; Schmitt, Gertrud; Venkatesan, Jagadeesh Kumar; Cucchiarini, Magali; Frisch, Janina (MDPI, 2019)[Abstract] Gene therapy for osteoarthritis offers powerful, long-lasting tools that are well adapted to treat such a slow, progressive disorder, especially those therapies based on the clinically adapted recombinant ... -
Enhanced Chondrogenic Differentiation Activities in Human Bone Marrow Aspirates via sox9 Overexpression Mediated by pNaSS-Grafted PCL Film-Guided rAAV Gene Transfer
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Meng, Weikun; Schmitt, Gertrud; Speicher-Mentges, Susanne; Falentin-Daudré, Céline; Leroux, Amélie; Madry, Henning; Migonney, Véronique; Cucchiarini, Magali (MDPI, 2020)[Abstract] Background: The delivery of therapeutic genes in sites of articular cartilage lesions using non-invasive, scaffold-guided gene therapy procedures is a promising approach to stimulate cartilage repair while ... -
Hydrogel-Guided, rAAV-Mediated IGF-I Overexpression Enables Long-Term Cartilage Repair and Protection against Perifocal Osteoarthritis in a Large-Animal Full-Thickness Chondral Defect Model at One Year In Vivo
Rey-Rico, Ana; Madry, Henning; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cai, Xiaoyu; Meng, Weikun; Cucchiarini, Magali; Maihöfer, Johanna; Goebel, Lars; Zurakowski, David; Menger, Michael D.; Laschke, Matthias W. (Wiley-VCH, 2021)[Abstract] The regeneration of focal articular cartilage defects is complicated by the reduced quality of the repair tissue and the potential development of perifocal osteoarthritis (OA). Biomaterial-guided gene therapy ... -
Improved Chondrogenic Differentiation of rAAV SOX9-Modified Human MSCs Seeded in Fibrin-Polyurethane Scaffolds in a Hydrodynamic Environment
Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Cucchiarini, Magali; Madry, Henning; Gardner, Oliver; Eglin, David; Alini, Mauro; Stoddart, Martin J. (MDPI, 2018)[Abstract] The repair of focal articular cartilage defects remains a problem. Combining gene therapy with tissue engineering approaches using bone marrow-derived mesenchymal stem cells (MSCs) may allow the development of ... -
Remodeling of human osteochondral defects via rAAV-mediated co-overexpression of TGF-β and IGF-I from implanted human bone marrow-derived mesenchymal stromal cells
Morscheid, Stephanie; Venkatesan, Jagadeesh Kumar; Rey-Rico, Ana; Schmitt, Gertrud; Cucchiarini, Magali (MDPI, 2019-08-28)[Abstract] The application of chondrogenic gene sequences to human bone marrow-derived mesenchymal stromal cells (hMSCs) is an attractive strategy to activate the reparative activities of these cells as a means to enhance ... -
Scaffold-Mediated Gene Delivery for Osteochondral Repair
Madry, Henning; Venkatesan, Jagadeesh Kumar; Carballo-Pedrares, Natalia; Rey-Rico, Ana; Cucchiarini, Magali (MDPI, 2020-09-29)[Abstract] Osteochondral defects involve both the articular cartilage and the underlying subchondral bone. If left untreated, they may lead to osteoarthritis. Advanced biomaterial-guided delivery of gene vectors has ... -
Therapeutic effects of rAAV-mediated concomittant gene transfer and overexpression of TGF-β and IGF-I on the chondrogenesis of human bone-marrow-derived mesenchymal stem cells
Morscheid, Stephanie; Rey-Rico, Ana; Schmitt, Gertrud; Madry, Henning; Cucchiarini, Magali; Venkatesan, Jagadeesh Kumar (MDPI, 2019-05-27)[Abstract] Application of chondroreparative gene vectors in cartilage defects is a powerful approach to directly stimulate the regenerative activities of bone-marrow-derived mesenchymal stem cells (MSCs) that repopulate ... -
Thermosensitive Hydrogel Based on PEO–PPO–PEO Poloxamers for a Controlled In Situ Release of Recombinant Adeno-Associated Viral Vectors for Effective Gene Therapy of Cartilage Defects
Madry, Henning; Rey-Rico, Ana; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Speicher-Mentges, Susanne; Cucchiarini, Magali; Goebel, Lars; Zurakowski, David; Laschke, Matthias W.; Cai, Xiaoyu; Menger, Michael D.; Gao, Liang; Müller-Brandt, Kathrin (WILEY-VCH, 2020)[Abstract] Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing for a controlled and minimally invasive delivery ...