Listar Grupos de investigación por autor "Ageitos, Lucía"
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Biologically Active Peptides from Venoms: Applications in Antibiotic Resistance, Cancer, and Beyond [Review]
Ageitos, Lucía; Torres, M. D. T.; Fuente, César de la (MDPI, 2022-12-06)[Abstract] Peptides are potential therapeutic alternatives against global diseases, such as antimicrobial-resistant infections and cancer. Venoms are a rich source of bioactive peptides that have evolved over time to act ... -
Datura stramonium Flowers as a Potential Natural Resource of Bioactive Molecules: Identification of Anti-Inflammatory Agents and Molecular Docking Analysis
Damergi, Bilel; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Tabbene, Olfa (MDPI, 2023-07-04)[Abstract] The present study investigated the antioxidant, antibacterial, antiviral and anti-inflammatory activities of different aerial parts (flowers, leaves and seeds) of Datura stramonium. The plant material was extracted ... -
FrpA Is the Outer Membrane Piscibactin Transporter in Vibrio Anguillarum: Structural Elements in Synthetic Piscibactin Analogues Required for Transport
Lages, Marta Afonso; De la Fuente, Carmen; Ageitos, Lucía; Martínez Matamoros, Diana; Rodríguez, Jaime; Balado, Miguel; Jiménez, Carlos; Lemos, Manuel L. (Springer Nature, 2021-11-18)[Abstract] Piscibactin (Pcb) is a labile siderophore widespread among Vibrionaceae. Its production is a major virulence factor of some fish pathogens such as Photobacterium damselae subsp. piscicida and Vibrio anguillarum. ... -
Identification of Key Functions Required for Production and Utilization of the Siderophore Piscibactin Encoded by the High-Pathogenicity Island irp-HPI in Vibrionaceae
Lages, Marta Afonso; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Lemos, Manuel L.; Balado, Miguel (MDPI, 2022)[Abstract] Piscibactin is a widespread siderophore system present in many different bacteria, especially within the Vibrionaceae family. Previous works showed that most functions required for biosynthesis and transport of ... -
In-Depth Analysis of the Role of the Acinetobactin Cluster in the Virulence of Acinetobacter baumannii
Conde-Pérez, Kelly; Vázquez-Ucha, Juan Carlos; Álvarez-Fraga, Laura; Ageitos, Lucía; Rumbo-Feal, Soraya; Martínez-Guitián, Marta; Trigo Tasende, Noelia; Rodríguez, Jaime; Bou, Germán; Jiménez, Carlos; Beceiro, Alejandro; Poza, Margarita (Frontiers, 2021-10-05)[Abstract] Acinetobacter baumannii is a multidrug-resistant pathogen that represents a serious threat to global health. A. baumannii possesses a wide range of virulence factors that contribute to the bacterial pathogenicity. ... -
Light-Emitting Probes for Labeling Peptides
Boaro, Andreia; Ageitos, Lucía; Torres, Marcelo; Bartoloni, Fernando Heering; De la Fuente, César (Cell Press, 2020-11-25)[Abstract] Peptides are versatile biopolymers composed of 2–100 amino acid residues that present a wide range of biological functions and constitute potential therapies for numerous diseases, partly due to their ability ... -
O-versus S-Metal Coordination of the Thiocarboxylate Group: An NMR Study of the Two Tautomeric Forms of the Ga(III)-Photoxenobactin E Complex
Buedenbender, Larissa; Ageitos, Lucía; Lages, Marta Afonso; Platas-Iglesias, Carlos; Balado, Miguel; Lemos, Manuel L.; Rodríguez, Jaime; Jiménez, Carlos (American Chemical Society, 2024-02-22)[Abstract] Photoxenobactin E (1) is a natural product with an unusual thiocarboxylic acid terminus recently isolated from an entomopathogenic bacterium. The biosynthetic gene cluster associated with photoxenobactin E, and ... -
Structural Requirements for Ga3+ Coordination in Synthetic Analogues of the Siderophore Piscibactin Deduced by Chemical Synthesis and Density Functional Theory Calculations
De la Fuente, Carmen; Ageitos, Lucía; Lages, Marta Afonso; Martínez Matamoros, Diana; Forero, Abel M.; Balado, Miguel; Lemos, Manuel L.; Rodríguez, Jaime; Jiménez, Carlos (American Chemical Society, 2023-05-04)[Abstract] Stereoselective total synthesis of several analogues of piscibactin (Pcb), the siderophore produced by different pathogenic Gram-negative bacteria, was performed. The acid-sensitive α-methylthiazoline moiety was ... -
Vibrio neptunius Produces Piscibactin and Amphibactin and Both Siderophores Contribute Significantly to Virulence for Clams
Galvis, Fabián; Ageitos, Lucía; Rodríguez, Jaime; Jiménez, Carlos; Barja, Juan L.; Lemos, Manuel L.; Balado, Miguel (Frontiers, 2021-10-25)[Abstract] Vibrio neptunius is an inhabitant of mollusc microbiota and an opportunistic pathogen causing disease outbreaks in marine bivalve mollusc species including oysters and clams. Virulence of mollusc pathogenic ...