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dc.contributor.authorLiu, Yong
dc.contributor.authorRan, Tao
dc.contributor.authorTenorio-Borroto, Esvieta
dc.contributor.authorTang, Shaoxun
dc.contributor.authorPazos, A.
dc.contributor.authorTan, Zhiliang
dc.contributor.authorGonzález-Díaz, Humberto
dc.date.accessioned2016-10-17T11:17:09Z
dc.date.issued2016-03-18
dc.identifier.citationLiu Y, Ran T, Tenorio-Barroto E, Tang S, Pazos A, Tan Z, et al. Experimental and chemometric studies of cell membrane permeability. Chemometrics Intelligent Lab Sys. 2016;154:1-6es_ES
dc.identifier.urihttp://hdl.handle.net/2183/17455
dc.description.abstract[Abstract] Cell membrane permeability (P) governs the molecules or ions to transport through the cell membrane. In this study, we measured P of ruminal microbes in different initial levels of surface tension (ST) and specific surface area (SSA). Data of P in present study and published data of pH, ammonia concentration, digestibility of neutral detergent fibre and gas production in two time scales (tk and ′tk) as input variables Vq(tk) were took into consideration for developing a predictive model. The ideas of Box–Jenkins Operators and Covariance Perturbation Theory Operators were used for the first time to establish a model to predict the variations of cellular permeability. The best model presented sensitivity, specificity and accuracy of > 0.89, and MCC > 0.78 for 77,781 cases (training + validation series). In addition, we also reported a simulation of ternary phase diagram with predicted values of cell permeability at various experimental conditions.es_ES
dc.description.sponsorshipNational Natural Science Foundation of China; Grant No. 31172234es_ES
dc.description.sponsorshipChinese Academy of Science and Technology Strategic Pilot Project; Grant No. XDA05020700es_ES
dc.description.sponsorshipHunan Provincial Natural Science Foundation of China; Grant No. 12JJ3015es_ES
dc.description.sponsorshipRed Gallega de Investigación sobre Cáncer Colorrectal; Ref. R2014/039es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation.urihttp://dx.doi.org/10.1016/j.chemolab.2016.03.010es_ES
dc.subjectCell membrane permeabilityes_ES
dc.subjectMoving averageses_ES
dc.subjectCovariancees_ES
dc.subjectPerturbation theoryes_ES
dc.subjectPredictive modeles_ES
dc.titleExperimental and chemometric studies of cell membrane permeabilityes_ES
dc.typeinfo:eu-repo/semantics/articlees_ES
dc.rights.accessinfo:eu-repo/semantics/embargoedAccesses_ES
dc.date.embargoEndDate2018-03-18es_ES
dc.date.embargoLift2018-03-18
UDC.journalTitleChemometrics and Intelligent Laboratory Systemses_ES
UDC.volume154es_ES
UDC.startPage1es_ES
UDC.endPage6es_ES


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