• Gender-Affirming Hormone Therapy Modifies the CpG Methylation Pattern of the ESR1 Gene Promoter After Six Months of Treatment in Transmen 

      Fernández, Rosa; Ramírez, Karla; Gómez-Gil, Esther; Cortés-Cortés, Joselyn; Mora, Mireia; Aranda, Gloria; Delgado Zayas, Enrique; Esteva de Antonio, Isabel; Almaraz, María Cruz; Guillamón, Antonio; Pásaro, Eduardo (2020)
      [Abstract] Background Brain sexual differentiation is a process that results from the effects of sex steroids on the developing brain. Evidence shows that epigenetics plays a main role in the formation of enduring brain ...
    • Genetic Polymorphism in Cytochrome P450 1B1 in a Spanish Population [Short Communication] 

      Pérez-Cadahía, Beatriz; Valdiglesias, Vanessa; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Wiley, 2007-06-02)
    • Genotoxicity of TiO2 Nanoparticles in Four Different Human Cell Lines (A549, HEPG2, A172 and SH-SY5Y) 

      Brandão, Fátima; Fernández‐Bertólez, Natalia; Rosário, Fernada; Bessa, Maria João; Fraga, Sónia; Pásaro, Eduardo; Teixeira, João; Laffon, Blanca; Valdiglesias, Vanessa; Costa, C. (2020)
      [Abstrac] Titanium dioxide nanoparticles (TiO2 NPs) have a wide variety of applications in many consumer products, including as food additives, increasing the concern about the possible hazards that TiO2 NPs may pose to ...
    • Identification of Differentially Expressed Genes in SHSY5Y Cells Exposed to Okadaic Acid by Suppression Subtractive Hybridization 

      Valdiglesias, Vanessa; Fernández-Tajes, Juan; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Springer Nature, 2012-01-27)
      [Abstract] Background: Okadaic acid (OA), a toxin produced by several dinoflagellate species is responsible for frequent food poisonings associated to shellfish consumption. Although several studies have documented the OA ...
    • Implications of the Estrogen Receptor Coactivators SRC1 and SRC2 in the Biological Basis of Gender Incongruence 

      Del Valle Ramírez, Karla; Fernández, Rosa; Delgado-Zayas, Enrique; Gómez-Gil, Esther; Esteva de Antonio, Isabel; Guillamon, Antonio; Pásaro, Eduardo (2021)
      [Abstract] Introduction Brain sexual differentiation results from the effects of sex steroids on the developing brain. The presumptive route for brain masculinization is the direct induction of gene expression via activation ...
    • Induction of Oxidative DNA Damage by the Marine Toxin Okadaic Acid Depends on Human Cell Type 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Cemeli, Eduardo; Anderson, Diana; Méndez, Josefina (Elsevier, 2011-03-01)
      [Abstract] The marine toxin okadaic acid (OA) is the main representative of diarrhoeic shellfish poisoning (DSP) toxins. Its ingestion induces nausea, vomiting, diarrhoea and abdominal ache. It has also been found to trigger ...
    • Innovación y empleo : lecciones de la pandemia del COVID-19 

      Romay Martínez, José; Vázquez Forno, Jesús; López-Cortón-Facal, Ana (Ministerio de Trabajo y Economía Social, 2023)
      [Resumen] En este trabajo se muestran algunos de los múltiples efectos perniciosos del Covid 19 que están afectando a toda la sociedad, principalmente en lo que concierne a la salud, la economía y el trabajo. A partir de ...
    • Inter-Laboratory Variation in DNA Damage Using a Standard Comet Assay Protocol 

      Forchhammer, Lykke; Ersson, Clara; Loft, Steffen; Möller, Lennart; Godschalk, Roger W. L.; Schooten, Frederik J. van; Jones, George D. D.; Higgins, Jennifer A.; Cooke, Marcus; Mistry, Vilas; Karbaschi, Mahsa; Collins, Andrew R.; Azqueta, Amaya; Phillips, David H.; Sozeri, Osman; Routledge, Michael N.; Nelson-Smith, Kirsty; Riso, Patrizia; Porrini, Marisa; Matullo, Giuseppe; Allione, Alessandra; Stępnik, Maciej; Komorowska, Magdalena; Teixeira, João Paulo; Costa, Solange; Corcuera, Laura-Ana; López de Cerain, Adela; Laffon, Blanca; Valdiglesias, Vanessa; Møller, Peter (Oxford University Press, 2012-07-27)
      [Abstract] There are substantial inter-laboratory variations in the levels of DNA damage measured by the comet assay. The aim of this study was to investigate whether adherence to a standard comet assay protocol would ...
    • Jubilación como evento social y preparación desde la empresa 

      Romay Martínez, José; López-Cortón-Facal, Ana; Martín Hernández, Pilar (Sibirana, 2019)
    • Low Vitamin D Levels and Frailty Status in Older Adults: a Systematic Review and Meta-Analysis 

      Marcos-Pérez, Diego; Sánchez-Flores, María; Bonassi, Stefano; Costa, Solange; Teixeira, João; Fernández-Tajes, Juan; Pásaro, Eduardo; Valdiglesias, Vanessa; Laffon, Blanca (2020)
      [Abstract] Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low ...
    • “Micronuclei and Disease” special issue: Aims, scope, and synthesis of outcomes 

      Fenech, Michael; Knasmueller, Siegfried; Knudsen, Lisbeth E.; Kirsch-Volders, Micheline; Deo, Permal; Franzke, Bernhard; Stopper, Helga; Andreassi, Maria-Grazia; Bolognesi, Claudia; Dhillon, Varinderpal S.; Laffon, Blanca; Wagner, Karl-Heinz; Bonassi, Stefano (2021)
      [Abastract] The purpose of the “Micronuclei and Disease” special issue (SI) is to: (i) Determine the level of evidence for association of micronuclei (MN), a biomarker of numerical and structural chromosomal aberrations, ...
    • Minimum Information for Reporting on the Comet Assay (MIRCA): Recommendations for Describing Comet Assay Procedures and Results 

      Møller, Peter; Azqueta, Amaya; Boutet-Robinet, Elisa; Koppen, Gudrun; Bonassi, Stefano; Milić, Mirta; Gajski, Goran; Costa, Solange; Teixeira, João; Pereira, Cristiana; Dusinska, Maria; Godschalk, Roger; Brunborg, Gunnar; Gützkow, Kristine Bjerve; Giovannelli, Lisa; Cooke, Marcus S.; Richling, Elke; Laffon, Blanca; Valdiglesias, Vanessa; Başaran, Nurşen; Del Bo’, Cristian; Zegura, Bojana; Novak, Matjaz; Stopper, Helga; Vodička, Pavel; Vodenkova, Sona; Andrade, Vanessa Moraes de; Sramkova, Monika; Gabelova, Alena; Collins, Andrew; Langie, Sabine (2020)
      [Abstract] The comet assay is a widely used test for the detection of DNA damage and repair activity. However, there are interlaboratory differences in reported levels of baseline and induced damage in the same experimental ...
    • Neuronal Cytotoxicity and Genotoxicity Induced by Zinc Oxide Nanoparticles 

      Valdiglesias, Vanessa; Costa, C.; Kiliç, Gözde; Costa, Solange; Pásaro, Eduardo; Laffon, Blanca; Teixeira, João Paulo (Elsevier, 2013-03-26)
      [Abstract] Zinc oxide nanoparticles (ZnO NPs) are one of the most abundantly used nanomaterials in consumer products and biomedical applications. As a result, human exposure to these NPs is highly frequent and they have ...
    • Nuevos modelos de atención sanitaria para las personas transgénero en el sistema sanitario español: demandas, controversias y reflexiones 

      Gómez-Gil, Esther; Esteva de Antonio, Isabel; Fernández Rodríguez, María; Almaraz, María Cruz; Hurtado Murillo, Felipe; Gómez Balaguer, Marcelino; Asenjo Araque, Nuria; Mora Porta, Mireia; Halperin Rabinovich, Irene; Fernández, Rosa; Montejo González, Ángel Luis; Grupo Gidseen (2020)
      [Resumen] La atención sanitaria a las personas transgénero en España se ha establecido de manera progresiva desde 1999, año en que Andalucía crea la primera unidad multidisciplinar para el tratamiento integral de la ...
    • Okadaic Acid Induces Morphological Changes, Apoptosis and Cell Cycle Alterations in Different Human Cell Types 

      Valdiglesias, Vanessa; Laffon, Blanca; Pásaro, Eduardo; Méndez, Josefina (Royal Society of Chemistry (Gran Bretaña), 2011-03-28)
      [Abstract] Okadaic acid (OA) is a marine toxin produced by dinoflagellate species which is frequently accumulated in molluscs usual in the human diet. The exact action mechanism of OA has not been described yet and the ...
    • Okadaic Acid Meet and Greet: An Insight into Detection Methods, Response Strategies and Genotoxic Effects in Marine Invertebrates 

      Prego-Faraldo, María Verónica; Valdiglesias, Vanessa; Méndez, Josefina; Eirín-López, J.M. (Multidisciplinary Digital Publishing Institute, 2013)
      Harmful Algal Blooms (HABs) constitute one of the most important sources of contamination in the oceans, producing high concentrations of potentially harmful biotoxins that are accumulated across the food chains. One such ...
    • Okadaic Acid: More than a Diarrheic Toxin 

      Valdiglesias, Vanessa; Prego-Faraldo, María Verónica; Pásaro, Eduardo; Méndez, Josefina; Laffon, Blanca (Multidisciplinary Digital Publishing Institute, 2013)
      Okadaic acid (OA) is one of the most frequent and worldwide distributed marine toxins. It is easily accumulated by shellfish, mainly bivalve mollusks and fish, and, subsequently, can be consumed by humans causing alimentary ...
    • Reflexión sobre la implementación de un instrumento de evaluación cognitiva en Terapia Ocupacional : la batería de evaluación cognitiva loewenstein occupational therapy cognitive assessment (LOTCA) 

      Ávila Álvarez, Adriana I.; Viana-Moldes, Inés; Torres-Tobío, Gabriel; López-Cortón-Facal, Ana (COTOGA, 2010-02)
      [Resumen] Este artículo pretende informar y aclarar las dudas, errores de interpretación y necesidades que han aparecido entre los alumnos y profesionales de terapia ocupacional, entre los años 2004 al 2009, en relación ...
    • Salivary Leucocytes as In Vitro Model to Evaluate Nanoparticle-Induced DNA Damage 

      Valdiglesias, Vanessa; Fernández-Bertólez, Natalia; Lema-Arranz, Carlota; Rodríguez-Fernández, Raquel; Pásaro, Eduardo; Reis, Ana Teresa; Teixeira, João; Costa, C.; Laffon, Blanca (MDPI, 2021-07-27)
      [Abstract] Metal oxide nanoparticles (NPs) have a wide variety of applications in many consumer products and biomedical practices. As a result, human exposure to these nanomaterials is highly frequent, becoming an issue ...
    • Sociedad urbana e inmigración en España : nuevo marco de las relaciones grupales 

      Romay Martínez, José; López-Cortón-Facal, Ana; Gil-Lacruz, Marta (Universidad de Lima, 2012-03-02)
      [Resumen] De ser un país de emigrantes, España se ha convertido en poco tiempo, en un foco importante de inmigrantes que acuden a sus ciudades principales. En épocas de crisis e incertidumbre como la nuestra, a menudo el ...