Listar GI-FENM - Artigos por autor "Sangiao-Alvarellos, Susana"
Mostrando ítems 1-20 de 38
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Altered fasting and postprandial plasma ghrelin levels in patients with liver failure are normalized after liver transplantation
Diz-Lois, María Teresa; García-Buela, Jesús; Suárez, Francisco; Sangiao-Alvarellos, Susana; Vidal, Ovidio; Cordido, Fernando (Bioscientifica para European Society for Endocrinology, 2010)[Abstract] Context Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Experimental data exist, which suggest that ghrelin ... -
Altered GH-IGF-1 axis in severe obese subjects is reversed after bariatric surgery-induced weight loss and related with low-grade chronic inflammation
Juiz-Valiña, Paula; Pena-Bello, Lara; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-08-12)[Abstract] Endocrine disorders are common in obesity, including altered somatotropic axis. Obesity is characterized by reduced growth hormone (GH) secretion, although the insulin-like growth factor-1 (IGF-1) values are ... -
Beneficial effects of bariatric surgery-induced by weight loss on the proteome of abdominal subcutaneous adipose tissue
Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Varela, Luis; Outeiriño-Blanco, Elena; García-Brao, María Jesús; Mena, Enrique; Noguera, José Francisco; Valero-Gasalla, Javier; Cordido, Fernando; Sangiao-Alvarellos, Susana; Bravo, Susana Belén (MDPI, 2020-01-13)[Abstract] Bariatric surgery (BS) is the most effective treatment for obesity and has a positive impact on cardiometabolic risk and in the remission of type 2 diabetes. Following BS, the majority of fat mass is lost from ... -
Cellular distribution, regulated expression, and functional role of the anorexigenic peptide, NUCB2/nesfatin-1, in the testis
García-Galiano, David; Pineda, Rafael; Ilhan, Tuncay; Castellano, Juan Manuel; Ruiz-Pino, Francisco; Sánchez-Garrido, Miguel Ángel; Vázquez, M.J.; Sangiao-Alvarellos, Susana; Romero-Ruiz, Antonio; Pinilla, Leonor; García-Diéguez, Carlos; Gaytán, Francisco; Tena-Sempere, Manuel (Oxford Academic, 2012-02-14)[Abstract] Nesfatin-1, product of the precursor NEFA/nucleobindin2 (NUCB2), was initially identified as anorectic hypothalamic neuropeptide, acting in a leptin-independent manner. In addition to its central role in the ... -
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
Sangiao-Alvarellos, Susana; Vázquez, María J.; Varela, Luis; Nogueiras, Rubén; Saha, Asish K.; Cordido, Fernando; López, Miguel; Diéguez, Carlos (Oxford para Endocrine Society, 2009-10-01)[Abstract] GH plays a major role in the regulation of lipid metabolism and alterations in GH axis elicit major changes in fat distribution and mobilization. For example, in patients with GH deficiency (GHD) or in mice ... -
Central resistance to thyroid hormones in morbidly obese subjects is reversed after bariatric surgery-induced weight loss
Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2020-01-28)[Abstract] Endocrine abnormalities are common in obesity, including altered thyroid function. The altered thyroid function of obesity may be due to a mild acquired resistance to the thyroid hormone. The aim of this study ... -
Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty
Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013)[Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ... -
Circulating levels of irisin in hypopituitary and normal subjects
Pena-Bello, Lara; Pértega-Díaz, Sonia; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Eiras-Leal, Raquel; Varela-Rodríguez, Bárbara María; Juiz-Valiña, Paula; Pérez-Fontán, Miguel; Cordido, María; Cordido, Fernando (PLoS ONE, 2016-07-29)[Abstract] Context. The recently identified myokine irisin conveys some of the benefits of exercise. Hypopituitarism with adult growth hormone deficiency (HP) is a situation characterized by decreased GH secretion and an ... -
Cost-effectiveness analysis of preoperative treatment of acromegaly with somatostatin analogue on surgical outcome
Margusino-Framiñán, Luis; Pértega-Díaz, Sonia; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Outeiriño-Blanco, Elena; Pita-Gutiérrez, Francisco; Pita-Fernández, Salvador; Cordido, Fernando (Elsevier, 2015-08-20)[Abstract] Context. There is no uniform standard of care for acromegaly. Due to the high costs involved, steps must be taken to ensure the cost-effective delivery of treatment. Objective. Taking the results of an earlier ... -
Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism
Gaytán, Francisco; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; García-Galiano, David; Ruiz-Pino, Francisco; Romero-Ruiz, Antonio; León, Silvia; Morales, Concepción; Cordido, Fernando; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013-01-21)[Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ... -
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications
Sangiao-Alvarellos, Susana; Cordido, Fernando (Hindawi, 2010)[Abstract] Ghrelin is a 28-amino-acid peptide that displays a strong growth hormone- (GH-) releasing activity through the activation of the growth hormone secretagogue receptor (GHSR). The first studies about role of ghrelin ... -
Effect of oral glucose administration on rebound growth hormone release in normal and obese women: the role of adiposity, insulin sensitivity and ghrelin
Pena-Bello, Lara; Pértega-Díaz, Sonia; Outeiriño-Blanco, Elena; García-Buela, Jesús; Tovar, Sulay; Sangiao-Alvarellos, Susana; Diéguez, Carlos; Cordido, Fernando (PLoS ONE, 2015-03-17)[Abstract] Context. Metabolic substrates and nutritional status play a major role in growth hormone (GH) secretion. Uncovering the mechanisms involved in GH secretion following oral glucose (OG) administration in normal ... -
Effect of weight loss after bariatric surgery on thyroid-stimulating hormone levels in euthyroid patients with morbid obesity
Juiz-Valiña, Paula; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Varela-Rodríguez, Bárbara María; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Cordido, María; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2019-05-20)[Abstract] Obesity is associated with several endocrine abnormalities, including thyroid dysfunction. The objective of this study was to investigate the effect of weight loss after bariatric surgery on thyroid-stimulating ... -
Evaluation of thyroid hormone replacement dosing in morbidly obese hypothyroid patients after bariatric surgery-induced weight loss
Juiz-Valiña, Paula; Cordido, María; Outeiriño-Blanco, Elena; Pértega-Díaz, Sonia; Urones Cuesta, Paula; García-Brao, María Jesús; Mena, Enrique; Pena-Bello, Lara; Sangiao-Alvarellos, Susana; Cordido, Fernando (MDPI, 2021-08-19)[Abstract] The most frequent endocrine disease in obese patients is hypothyroidism. To date, there are no clear data regarding what happens to the dose of levothyroxine (LT4) after bariatric surgery (BS). The objective of ... -
Fasting and postprandial plasma ghrelin levels are decreased in patients with liver failure previous to liver transplantation
Diz-Lois, María Teresa; García-Buela, Jesús; Suárez, Francisco; Sangiao-Alvarellos, Susana; Vidal, Ovidio; Cordido, Fernando (Spirnger, 2009-04-11)[Abstract] Anorexia is a problem of paramount importance in patients with advanced liver failure. Ghrelin has important actions on feeding and weight homeostasis. Concentrations of ghrelin are controversial in liver ... -
FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
Varela-Rodríguez, Bárbara María; Pena-Bello, Lara; Juiz-Valiña, Paula; Vidal Bretal, Beatriz; Cordido, Fernando; Sangiao-Alvarellos, Susana (Nature, 2016-07-19)[Abstract] Irisin is processed from fibronectin type III domain-containing protein 5 (FNDC5). However, a controversy exists concerning irisin origin, regulation and function. To elucidate the relationship between serum ... -
Función endocrina en la obesidad
Álvarez Castro, Paula; Sangiao-Alvarellos, Susana; Brandón-Sandá, Iria; Cordido, Fernando (Elsevier, 2011-08-06)[Resumen] La obesidad se asocia con importantes anomalías en la función endocrina. La hiper insulinemia y la resistencia a la insulina son las dos alteraciones mejor conocidas, aunque sus mecanismos y su significado clínico ... -
Ghrelin and growth hormone secretagogues, physiological and pharmacological aspect
Cordido, Fernando; Isidro, María Luisa; Nemina, Rosa; Sangiao-Alvarellos, Susana (Bentham Science, 2009)[Abstract] The first “growth hormone secretagogues” (GHSs) were discovered by Bowers et al. in 1977. In 1996 the GHSs receptor (GHS-R 1a) was cloned. The endogenous ligand for this receptor, ghrelin, was not identified ... -
Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism
Sangiao-Alvarellos, Susana; Helming, Steffen; Vázquez, María J.; Klussmann, Sven; Cordido, Fernando (Elsevier, 2011)[Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ... -
Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese women
Outeiriño-Blanco, Elena; García-Buela, Jesús; Sangiao-Alvarellos, Susana; Pértega-Díaz, Sonia; Martínez-Ramonde, T.; Cordido, Fernando (Thieme, 2011-06-10)[Abstract] The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Ghrelin is a peptide that ...