Now showing items 21-40 of 94

    • Fructose transporter Glut5 expression in clear renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valbuena Ruvira, L.; García Campelo, R.; Valladares-Ayerbes, Manuel; Grande Pulido, Enrique; Bolós Fernández, Victoria; Santamarina, Isabel; Antón-Aparicio, Luis M. (Spandidos, 2010-12-10)
      [Abstract] Renal cell carcinomas (RCC) can be subclassified for general purposes into clear cell, papillary cell, chromophobe cell carcinomas and oncocytomas. Other tumours such as collecting duct, medullary, mucinous ...
    • Relevant networks involving the p53 signalling pathway in renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valbuena Ruvira, L.; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Master Publishing Group, 2011)
      [Abstract] Introduction: Renal cell carcinoma is the most common type of kidney cancer. A better understanding of the critical pathways and interactions associated with alterations in renal function and renal tumour ...
    • Ghrelin neutralization during fasting-refeeding cycle impairs the recuperation of body weight and alters hepatic energy metabolism 

      Sangiao-Alvarellos, Susana; Helming, Steffen; Vázquez, María J.; Klussmann, Sven; Cordido, Fernando (Elsevier, 2011)
      [Abstract] Ghrelin, a hormone whose levels increase during food deprivation, plays a pivotal role in the regulation of food intake, energy metabolism and storage, as well as in insulin sensitivity. Here, we investigated ...
    • Aspectos médicos del tratamiento quirúrgico de la obesidad 

      Morales, María José; Díaz-Fernández, María Jesús; Caixàs, Assumpta; Cordido, Fernando (Elsevier, 2011)
    • Ghrelin and lipid metabolism: key partners in energy balance 

      Varela, Luis; Vázquez, María J.; Cordido, Fernando; Nogueiras, Rubén; Vidal-Puig, Antonio; Diéguez, Carlos; López, Miguel (Bioscientifica para Society for Endocrinoloogy, 2011-04-01)
      [Abstract] Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates ...
    • Growth hormone, ghrelin and peptide YY secretion after oral glucose administration in healthy and obese women 

      Outeiriño-Blanco, Elena; García-Buela, Jesús; Sangiao-Alvarellos, Susana; Pértega-Díaz, Sonia; Martínez-Ramonde, T.; Cordido, Fernando (Thieme, 2011-06-10)
      [Abstract] The mechanism of the altered GH secretion in obesity is unclear. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Ghrelin is a peptide that ...
    • Prognostic impact of disseminated tumor cells and microRNA-17-92 cluster deregulation in gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Blanco, Moisés; Haz, Mar; Medina, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; Reboredo, Margarita; Santamarina, Isabel; Figueroa, Angélica; Antón-Aparicio, Luis M.; Calvo, Lourdes (Spandidos, 2011-07-04)
      [Abstract] The presence of tumor cells in the bone marrow (BM) could be relevant to identifying high risk of disease progression and death in gastrointestinal cancer. However, the molecular profile associated with disseminated ...
    • Función endocrina en la obesidad 

      Álvarez Castro, Paula; Sangiao-Alvarellos, Susana; Brandón-Sandá, Iria; Cordido, Fernando (Elsevier, 2011-08-06)
      [Resumen] La obesidad se asocia con importantes anomalías en la función endocrina. La hiper insulinemia y la resistencia a la insulina son las dos alteraciones mejor conocidas, aunque sus mecanismos y su significado clínico ...
    • Clinical manifestations and diagnosis of acromegaly 

      Lugo, Gloria; Pena, Lara; Cordido, Fernando (Hindawi, 2012)
      [Abstract] Acromegaly and gigantism are due to excess GH production, usually as a result of a pituitary adenoma. The incidence of acromegaly is 5 cases per million per year and the prevalence is 60 cases per million. ...
    • Role of neurokinin B in the control of female puberty and Its modulation by metabolic status 

      Navarro, Víctor M.; Ruiz-Pino, Francisco; Sánchez-Garrido, Miguel A.; García-Galiano, David; Hobbs, Samuel J.; Manfredi-Lozano, María; León, Silvia; Sangiao-Alvarellos, Susana; Castellano, Juan M.; Clifton, Donald K.; Pinilla, Leonor; Steiner, Robert A.; Tena-Sempere, Manuel (Society of Neuroscience, 2012-02-15)
      [Abstract] Human genetic studies have revealed that neurokinin B (NKB) and its receptor, neurokinin-3 receptor (NK3R), are essential elements for normal reproduction; however, the precise role of NKB–NK3R signaling in the ...
    • Sexual dimorphism on growth hormone secretion after oral glucose administration 

      Outeiriño-Blanco, Elena; García-Buela, Jesús; Sangiao-Alvarellos, Susana; Brandón-Sandá, Iria; Pena-Bello, Lara; Pértega-Díaz, Sonia; Martínez, T.; Cordido, Fernando (Thieme, 2012-02-16)
      [Abstract] Sexual dimorphism of GH secretion is unclear in humans. There is evidence that oral glucose (OG) administration initially decreases and subsequently stimulates GH secretion. Our aim was to study fasting GH ...
    • A primary signet ring cell carcinoma of the prostate with bone metastasis with impressive response to FOLFOX and Cetuximab 

      Roldán, Ana Milena; Fernández-Núñez, Natalia; Grande Pulido, Enrique; Álvarez-García, Augusto; Antón-Aparicio, Luis M. (Elsevier, 2012-03-10)
    • State of the art in silico tools for the study of signaling pathways in cancer 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (MDPI, 2012-05-29)
      [Abstract] In the last several years, researchers have exhibited an intense interest in the evolutionarily conserved signaling pathways that have crucial roles during embryonic development. Interestingly, the malfunctioning ...
    • Circulating microRNAs: molecular microsensors in gastrointestinal cancer 

      Blanco, Moisés; Calvo, Lourdes; Figueroa, Angélica; Haz, Mar; Antón-Aparicio, Luis M.; Valladares-Ayerbes, Manuel (MPDI, 2012-07-09)
      [Abstract] MicroRNAs (miRNAs) are small molecules of single strand non-coding RNAs, which are able to regulate gene expression. miRNAs have been involved in multiple cellular processes, such as proliferation, apoptosis and ...
    • Searching for Hif1-α interacting proteins in renal cell carcinoma 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Santamarina, Isabel; Valladares-Ayerbes, Manuel; Antón-Aparicio, Luis M. (Springer para Federation of Spanish Oncology Sociesties (FESEO), 2012-08-28)
      [Abstract] Introduction. Kidney tumours are frequently characterised by hypoxic conditions due to a local imbalance between oxygen (O2) supply and consumption. Hif1-α regulates angiogenesis, tumour growth, tumour progression, ...
    • Multiple biomarker tissue arrays: a computational approach to identifying protein-protein interactions in the EGFR/ERK signalling pathway 

      Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Valladares-Ayerbes, Manuel; Santamarina, Isabel; Antón-Aparicio, Luis M. (BioMed Central, 2012-09-01)
      [Abstract] Background. Many studies have demonstrated genetic and environmental factors that lead to renal cell carcinoma (RCC) and that occur during a protracted period of tumourigenesis. It appears suitable to identify ...
    • Crossing paths in Human Renal Cell Carcinoma (hRCC) 

      Aparicio Gallego, Guadalupe; Medina Villaamil, Vanessa; Grande Pulido, Enrique; Santamarina, Isabel; Antón-Aparicio, Luis M. (MDPI, 2012-10-05)
      [Abstract] Historically, cell-signaling pathways have been studied as the compilation of isolated elements into a unique cascade that transmits extracellular stimuli to the tumor cell nucleus. Today, growing evidence ...
    • Changes in hypothalamic expression of the Lin28/let-7 system and related MicroRNAs during postnatal maturation and after experimental manipulations of puberty 

      Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; Ruiz-Pino, Francisco; Navarro, V.M.; Sánchez-Garrido, M.A.; León, Silvia; Diéguez, Carlos; Cordido, Fernando; Matagne, V.; Dissen, G.A.; Ojeda, S.R.; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013)
      [Abstract] Lin28 and Lin28b are related RNA-binding proteins that inhibit the maturation of miRNAs of the let-7 family and participate in the control of cellular stemness and early embryonic development. Considerable ...
    • Distinct expression patterns predict differential roles of the miRNA-binding proteins, Lin28 and Lin28b, in the mouse testis: studies during postnatal development and in a model of hypogonadotropic hypogonadism 

      Gaytán, Francisco; Sangiao-Alvarellos, Susana; Manfredi-Lozano, María; García-Galiano, David; Ruiz-Pino, Francisco; Romero-Ruiz, Antonio; León, Silvia; Morales, Concepción; Cordido, Fernando; Pinilla, Leonor; Tena-Sempere, Manuel (Endocrine Society, 2013-01-21)
      [Abstract] Lin28 (also termed Lin28a) and Lin28b are related RNA-binding proteins, involved in the control of microRNA synthesis, especially of the let-7 family, with putative functions in early (embryo) development. ...
    • Efficacy of glutamine in the prevention of acute radiation enteritis: a randomized controlled trial 

      Vidal-Casariego, Alfonso; Calleja-Fernández, Alicia; Ortiz de Urbina-González, Juan José; Cano-Rodríguez, Isidoro; Cordido, Fernando; Ballesteros-Pomar, María D. (SAGE, 2013-03-07)
      [Abstract] Background: Acute radiation enteritis is a common adverse effect related to radiotherapy (RT). Glutamine is an immune modulator and antioxidant amino acid that can exert a protective role in patients receiving ...