Now showing items 1-8 of 8

    • Bioinformatics approach to mRNA markers discovery for detection of circulating tumor cells in patients with gastrointestinal cancer 

      Valladares-Ayerbes, Manuel; Díaz-Prado, Silvia; Reboredo, Margarita; Medina Villaamil, Vanessa; Iglesias-Díaz, Pilar; Lorenzo-Patiño, María J.; García Campelo, Rosario; Haz, Mar; Santamarina, Isabel; Antón-Aparicio, Luis M. (Elsevier, 2008)
      [Abstract] Background: Detection of tumor cells in the blood, or minimal deposits in distant organs as bone marrow, could be important to identify cancer patients at high risk of relapse or disease progression. Quantitative ...
    • Cyclooxygenase-2 (COX-2): a molecular target in prostate cancer 

      Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Casinello Espinosa, J.; Antón-Aparicio, Luis M. (Springer, 2007-12-15)
      [Abstract] Epidemiological studies provided the first evidence that COX may be involved in the pathogenesis of cancer. In the process of carcinogenesis and in the route of intracellular signalling during carcinogenesis, ...
    • Expression of Wnt gene family and frizzled receptors in head and neck squamous cell carcinomas 

      Díaz-Prado, Silvia; Medina Villaamil, Vanessa; Aparicio Gallego, Guadalupe; Blanco, Moisés; López Cedrún, José Luis; Sironvalle Soliva, Sheila; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Antón-Aparicio, Luis M. (Spirnger, 2009)
      [Abstract] Genes of the Wnt and Frizzled class, expressed in HNSCC tissue and cell lines, have an established role in cell morphogenesis and differentiation, and also they have oncogenic properties. We studied Wnt and Fz ...
    • Glucose transporter expression and the potential role of fructose in renal cell carcinoma: a correlation with pathological parameters 

      Antón-Aparicio, Luis M.; Medina Villaamil, Vanessa; Blanco, Moisés; Valbuena Ruvira, L.; Rois, José Manuel; Valladares-Ayerbes, Manuel; García Campelo, Rosario; Bolós Fernández, Victoria; Grande Pulido, Enrique (Spandidos, 2010-07-01)
      [Abstract] All mammalian cells contain one or more members of the facilitative glucose transporter (GLUT) gene family. Glucose transporter membrane proteins (GLUT) regulate the movement of glucose between the extracellular ...
    • Origin of renal cell carcinomas 

      Valladares-Ayerbes, Manuel; Aparicio Gallego, Guadalupe; Díaz-Prado, Silvia; Jiménez Fonseca, P.; García Campelo, Rosario; Antón-Aparicio, Luis M. (Springer, 2008-11-28)
      [Abstract] Cancer is a heritable disorder of somatic cells: environment and heredity are both important in the carcinogenic process. The primal force is the “two hits” of Knudson’s hypothesis, which has proved true for ...
    • Potential role of sugar transporters in cancer and their relationship with anticancer therapy 

      Blanco, Moisés; Figueroa, Angélica; Grande Pulido, Enrique; García Campelo, Rosario; Antón-Aparicio, Luis M. (Hindawi, 2010-06-20)
      [Abstract] Sugars, primarily glucose and fructose, are the main energy source of cells. Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. ...
    • Prostate cancer and Hedgehog signalling pathway 

      Antón-Aparicio, Luis M.; García Campelo, Rosario; Casinello Espinosa, J.; Valladares-Ayerbes, Manuel; Reboredo, Margarita; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-08-02)
      [Abstract] The Hedgehog (Hh) family of intercellular signalling proteins have come to be recognised as key mediators in many fundamental processes in embryonic development. Their activities are central to the growth, ...
    • Prostate carcinoma and stem cells 

      Antón-Aparicio, Luis M.; Cassinello Espinosa, J.; García Campelo, Rosario; Gómez Veiga, Francisco; Díaz-Prado, Silvia; Aparicio Gallego, Guadalupe (Springer, 2007-02)
      [Abstract] Stem cells, as classically defined, are cells with a capacity to self-renew and to generate daughter cells that can differentiate down several cell lineages to form all of the cell types that are found in the ...