Browsing by Author "Caramés, Beatriz"
Now showing items 1-4 of 4
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Defective chaperone-mediated autophagy is a hallmark of joint disease in patients with knee osteoarthritis
Lorenzo-Gómez, I.; Nogueira Recalde, Uxía; García-Domínguez, C.; Oreiro, Natividad; Lotz, Martin; Pinto-Tasende, José A.; Blanco García, Francisco J; Caramés, Beatriz (Elsevier, 2023-03-08)[Abstract] Objective: Defects in autophagy contribute to joint aging and Osteoarthritis (OA). Identifying specific autophagy types could be useful for developing novel treatments for OA. Design: An autophagy-related ... -
Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy
Nogueira Recalde, Uxía; Lorenzo Gómez, Irene; Blanco García, Francisco J; Loza, María Isabel; Grassi, Diego; Shirinsky, Valery; Shirinsky, Ivan; Lotz, Martin; Robbins, Paul D.; Domínguez, Eduardo; Caramés, Beatriz (Elsevier, 2019-07-05)[Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available. Our objective was ... -
Mitochondrial activity is modulated by TNFα and IL-1β in normal human chondrocyte cells
López-Armada, María José; Caramés, Beatriz; Martín, M.A.; Cillero-Pastor, B.; Lires-Dean, M.; Fuentes Boquete, Isaac Manuel; Arenas, J.; Blanco García, Francisco J (Elsevier, 2006-05-05)[Abstract] Objective. Pro-inflammatory cytokines play an important role in osteoarthritis (OA). In osteoarthritic cartilage, chondrocytes exhibit an alteration in mitochondrial activity. This study analyzes the effect of ... -
Reduced levels of H₂S in diabetes-associated osteoarthritis are linked to hyperglycaemia, Nrf-2/HO-1 signalling downregulation and chondrocyte dysfunction
Piñeiro-Ramil, María; Burguera, Elena F.; Hermida-Gómez, Tamara; Caramés, Beatriz; Oreiro, Natividad; Meijide-Faílde, Rosa; Blanco García, Francisco J; Vaamonde-García, Carlos (MDPI, 2022-03-25)[Abstract] Different findings indicate that type 2 diabetes is an independent risk factor for osteoarthritis (OA). However, the mechanisms underlying the connection between both diseases remain unclear. Changes in the ...