Browsing by Subject "JAK/STAT"

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IL6/sIL6R regulates TNFα-inflammatory response in synovial fibroblasts through modulation of transcriptional and post-transcriptional mechanisms

Valin, Álvaro; Del Rey, Manuel J.; Municio, Cristina; Usategui, Alicia; Romero, Marina; Fernández-Felipe, Jesús; Cañete, Juan D.; Blanco García, Francisco J; Ruano, Yolanda; Criado, Gabriel; Pablos, José L. (BioMed Central, 2020-10-30)

[Abstract] Introduction: The clinical efficacy of specific interleukin-6 inhibitors has confirmed the central role of IL6 in rheumatoid arthritis (RA). However the local role of IL6, in particular in synovial fibroblasts ...