Listar por tema "Genetics"
Mostrando ítems 1-12 de 12
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Atlas of the clinical genetics of human dilated cardiomyopathy
(Oxford para European Society of Cardiology, 2014-08-27)[Abstract] Aim. Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM ... -
Cellular and Molecular Mechanisms Underlying Glioblastoma and Zebrafish Models for the Discovery of New Treatments
(MDPI, 2021-03-03)[Abstract] Glioblastoma (GBM) is the most common of all brain malignant tumors; it displays a median survival of 14.6 months with current complete standard treatment. High heterogeneity, aggressive and invasive behavior, ... -
Evaluation of Existing Methods for High-Order Epistasis Detection
(Institute of Electrical and Electronics Engineers, 2020-10-15)[Abstract] Finding epistatic interactions among loci when expressing a phenotype is a widely employed strategy to understand the genetic architecture of complex traits in GWAS. The abundance of methods dedicated to the ... -
Genetic biomarkers in osteoarthritis: a quick overview
(Faculty Opinions, 2021-11-10)[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. ... -
Mitochondrial genetics and epigenetics in osteoarthritis
(Frontiers, 2020-01-17)[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial ... -
mtDNA Haplogroup A Enhances the Effect of Obesity on the Risk of Knee OA in a Mexican Population
(Nature, 2022-03-25)[Abstract] To evaluate the influence of mitochondrial DNA haplogroups on the risk of knee OA in terms of their interaction with obesity, in a population from Mexico. Samples were obtained from (n = 353) knee OA patients ... -
Parallel Pairwise Epistasis Detection on Heterogeneous Computing Architectures
(Institute of Electrical and Electronics Engineers, 2016-08)[Abstract] Development of new methods to detect pairwise epistasis, such as SNP-SNP interactions, in Genome-Wide Association Studies is an important task in bioinformatics as they can help to explain genetic influences on ... -
Protocolo diagnóstico de las miocardiopatías genéticas
(Elsevier, 2017-10-29)[Resumen] Características generales. Las miocardiopatías genéticas engloban un grupo heterogéneo de enfermedades. Algunas afectan de forma aislada al músculo cardíaco, en otros casos forman parte del espectro de una ... -
Proyecto divulgativo: genética y evolución (domesticación) del maíz
(2021)[Resumen]: La divulgación científica nace de la necesidad de transmitir conocimiento a un público no especializado. En este proyecto de divulgación se aborda la domesticación del maíz, que es uno de los cereales más ... -
Revisión bibliográfica: A homosexualidade en animais
(2023)[Resumen] La homosexualidad animal es una conducta controvertida debido a su relación con el debate de la homosexualidad humana. Aparte de ello, su existencia y persistencia parece suponer un coste para la fitness. En ... -
Risk Predictors in a Spanish Cohort With Cardiac Laminopathies. The REDLAMINA Registry
(Elsevier, 2020-06-29)[Abstract] Introduction and objectives. According to sudden cardiac death guidelines, an implantable cardioverter-defibrillator (ICD) should be considered in patients with LMNA-related dilated cardiomyopathy (DCM) and ... -
RuII(p-cymene) Compounds as Effective and Selective Anticancer Candidates with No Toxicity in Vivo
(American Chemical Society (ACS), 2018-10-19)[Abstract] Ruthenium(II) complexes are currently considered a viable alternative to the widely used platinum complexes as efficient anticancer agents. We herein present the synthesis and characterization of half-sandwich ...
