Listar por tema "Gene expression"
Mostrando ítems 1-13 de 13
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A Novel Heterozygous Intronic Mutation in the FBN1 Gene Contributes to FBN1 RNA Missplicing Events in the Marfan Syndrome
(Hindawi, 2018)[Abstract] Marfan syndrome (MFS) is an autosomal dominantly inherited connective tissue disorder, mostly caused by mutations in the fibrillin-1 (FBN1) gene. We, by using targeted next-generation sequence analysis, identified ... -
A semantic interoperability approach to support integration of gene expression and clinical data in breast cancer
(Elsevier, 2017-06-05)[Abstract] Introduction. The introduction of omics data and advances in technologies involved in clinical treatment has led to a broad range of approaches to represent clinical information. Within this context, patient ... -
Análisis de la expresión del gen HMGB2 y relacionados en células de ovario tumorales en presencia de Olaparib
(2020)[Resumen]: El cáncer de ovario es una enfermedad de alta incidencia entre las mujeres postmenopáusicas (entre 50 y 75 años), que presenta una tasa de supervivencia del 60% a edades menores de 65 y de un 31% en ... -
Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma
(Frontiers, 2021)[Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding ... -
Efecto del cisplatino sobre la expresión de HMGB2 en células de cáncer de próstata (PC3)
(2019)[Resumen]: El cáncer de próstata es una enfermedad de alta incidencia entre la población masculina a nivel mundial, y tiene una elevada tasa de mortalidad. Su pronóstico y tratamiento dependen en gran medida de la fase ... -
Estudio de la inducción de resistencia en suspensiones celulares de pimiento (Capsicum annuum L. var. annuum) mediante la elicitación con extractos de hoja de Moringa oleifera
(2019)[Resumen]: En el presente trabajo se realizó un estudio de la inducción de resistencia en suspensiones celulares de Capsicum annuum L. var. annuum al ser elicitadas con extractos de Moringa oleifera. Para ello, se iniciaron ... -
Gastrointestinal Spatiotemporal mRNA Expression of Ghrelin vs Growth Hormone Receptor and New Growth Yield Machine Learning Model Based on Perturbation Theory
(Nature, 2016-07-27)[Abstract] The management of ruminant growth yield has economic importance. The current work presents a study of the spatiotemporal dynamic expression of Ghrelin and GHR at mRNA levels throughout the gastrointestinal tract ... -
Identification of an Elusive Spliceogenic MYBPC3 Variant in an Otherwise Genotype-Negative Hypertrophic Cardiomyopathy Pedigree
(Nature, 2022-05-04)[Abstract] The finding of a genotype-negative hypertrophic cardiomyopathy (HCM) pedigree with several affected members indicating a familial origin of the disease has driven this study to discover causative gene variants. ... -
Many heart transplant biopsies currently diagnosed as no rejection have mild molecular antibody-mediated rejection-related changes
(Elsevier, 2021-08-04)[Abstract] Background: The Molecular Microscope (MMDx) system classifies heart transplant endomyocardial biopsies as No-rejection (NR), Early-injury, T cell-mediated (TCMR), antibody-mediated (ABMR), mixed, and possible ... -
Metabolic flexibility in human chondrocytes, preliminary study.
(2023)[Abstract] Osteoarthritis (OA) is the most common rheumatic condition affecting joint tissues and is characterized by molecular and metabolic impairments. Chondrocytes, the only cell type in the cartilage, primarily rely ... -
Molecular states associated with dysfunction and graft loss in heart transplants
(Elsevier, 2023-11-30)[Abstract] Background: We explored the changes in gene expression correlating with dysfunction and graft failure in endomyocardial biopsies. Methods: Genome-wide microarrays (19,462 genes) were used to define mRNA ... -
Redefining the molecular rejection states in 3230 heart transplant biopsies: relationships to parenchymal injury and graft survival
(Elsevier, 2024-03-26)[Abstract] The first-generation Molecular Microscope (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose not only T cell-mediated rejection ... -
The Marine Toxin Okadaic Acid Induces Alterations in the Expression Level of Cancer-Related Genes in Human Neuronal Cells
(Elsevier, 2013-04-03)[Abstract] Okadaic acid (OA) is one of the most common and highly distributed marine toxins. It can be accumulated in several molluscs and other marine organisms and cause acute gastrointestinal symptoms after oral consumption ...