Listar por tema "Extracellular matrix"

Mostrando ítems 1-4 de 4

    • Analysis of endogenous peptides released from osteoarthritic articular cartilage unravels novel pathogenic markers 

      Fernández-Puente, Patricia; González-Rodríguez, Lucía; Calamia, Valentina; Picchi, Florencia; Lourido Salas, Lucía María; Camacho Encina, María; Oreiro, Natividad; Rocha Loureda, Beatriz; Paz González, Rocío; Marina, Anabel; García, Carlos; Blanco García, Francisco J; Ruiz-Romero, Cristina (American Society for Biochemistry and Molecular Biology (ASBMB), 2019-07-27)
      [Abstract] Osteoarthritis (OA) is a pathology characterized by the loss of articular cartilage. In this study, we performed a peptidomic strategy to identify endogenous peptides (neopeptides) that are released from human ...

    • Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma 

      Sanegre, Sabina; Eritja, Núria; Andrea, Carlos de; Díaz-Martín, Juan; Díaz-Lagares, Angel; Jácome, M. A.; Salguero Aranda, Carmen; García-Ros, David; Davidson, Ben; López-López, Rafael; Melero, Ignacio; Navarro, Samuel; Ramón y Cajal, Santiago; Alava, Enrique de; Matias-Guiu, Xavier; Noguera, Rosa (Frontiers, 2021)
      [Abstract] The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding ...

    • Extracellular Matrix in Heart Failure: Role of ADAMTS5 in Proteoglycan Remodeling 

      Barallobre-Barreiro, Javier; Radovits, Tamás; Fava, Marika; Mayr, Ursula; Lin, Wen-Yu; Ermolaeva, Elizaveta; Martínez-López, Diego; Lindberg, Eric L.; Duregotti, Elisa; Daróczi, László; Hasman, Maria; Schmidt, Lukas E.; Singh, Bhawana; Lu, Ruifang; Baig, Ferheen; Siedlar, Aleksandra Malgorzata; Cuello, Friederike; Catiborg, Norman; Theofilatos, Konstantinos; Shah, Ajay M.; Crespo-Leiro, María Generosa; Doménech, Nieves; Hübner, Norbert; Merkely, Béla; Mayr, Manuel (American Heart Association, 2021-11-22)
      [Abstract] Background: Remodeling of the extracellular matrix (ECM) is a hallmark of heart failure (HF). Our previous analysis of the secretome of murine cardiac fibroblasts returned ADAMTS5 (a disintegrin and metalloproteinase ...

    • Wnt and RUNX2 mediate cartilage breakdown by osteoarthritis synovial fibroblast‐derived ADAMTS‐7 and ‐12 

      Pérez-García, Selene; Carrión, Mar; Villanueva-Romero, Raúl; Hermida Gómez, Tamara; Fernández-Moreno, Mercedes; Mellado, Mario; Blanco García, Francisco J; Juarranz, Yasmina; Gomariz, Rosa P. (Wiley, 2019-03-22)
      [Abstract] Failure of therapeutic approaches for the treatment of osteoarthritis (OA) based on the inhibition of metalloproteinases, might be because of their constitutive expression in homeostasis, together with their ...