Listar por autor "Vila-Sanjurjo, Antón"
Mostrando ítems 1-13 de 13
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Aprendizaxe baseada en problemas en Xenética Molecular
Vila-Sanjurjo, Antón; Martínez Martínez, M. Luisa; Insua, Ana (Universidade da Coruña, Cufie, 2018)[Resumo] A aprendizaxe baseada en problemas (ABP) trátase dunha metodoloxía na que os alumnos, guiados polo profesor, deben resolver un problema. No proceso, os alumnos constrúen e aplican coñecementos en lugar de ser ... -
Circular PCR as an Efficient and Precise Umbrella of Methods for the Generation of Circular DsDNA With Staggered Nicks: Mechanism and Types
Ferro Gallego, Pedro Emilio; Vila-Sanjurjo, Antón; Valderrama Pereira, Andrea Katherine; Porres-Pérez, Gonzalo; Domínguez-Gerpe, María Lourdes (Oxford Academic, 2024-08-12)[Abstract] Here, we introduce the highly versatile circular polymerase chain reaction (CiPCR) technique, propose a mechanism of action, and describe a number of examples demonstrating the versatility of this technique. ... -
Covalently and Ionically, Dually Crosslinked Chitosan Nanoparticles Block Quorum Sensing and Affect Bacterial Cell Growth on a Cell-Density Dependent Manner
Vila-Sanjurjo, C.; Hembach, Lea; Netzer, Julius; Remuñán-López, Carmen; Vila-Sanjurjo, Antón; Goycoolea, Francisco M. (Elsevier, 2020-05-18)[Abstract] In our efforts to improve the quality and stability of chitosan nanoparticles (NPs), we describe here a new type of chitosan NPs dually crosslinked with genipin and sodium tripolyphosphate (TPP) that display ... -
Effect of the Ultrastructure of Chitosan Nanoparticles in Colloidal Stability, Quorum Quenching and Antibacterial Activities
Vila-Sanjurjo, C.; David, Laurent; Remuñán-López, Carmen; Vila-Sanjurjo, Antón; Goycoolea, Francisco M. (Elsevier, 2019-08-16)[Abstract] We have fabricated two types of crosslinked chitosan-based nanoparticles (NPs), namely (1) ionically crosslinked with tripolyphosphate (TPP), designated as IC-NPs and (2) dually co-crosslinked (ionically and ... -
Genotype to Phenotype: Diet-By-Mitochondrial DNA Haplotype Interactions Drive Metabolic Flexibility and Organismal Fitness
Aw, Wen Chyuan; Towarnicki, Samuel; Melvin, Richard G.; Youngson, Neil A.; Garvin, Michael; Hu, Yifang; Nielsen, Shaun; Thomas, Torsten; Pickford, Russell; Bustamante, Sonia; Vila-Sanjurjo, Antón; Smyth, Gordon K.; Ballard, J. William O. (Public Library of Science, 2018-11-06)[Abstract] Diet may be modified seasonally or by biogeographic, demographic or cultural shifts. It can differentially influence mitochondrial bioenergetics, retrograde signalling to the nuclear genome, and anterograde ... -
Heterologous Inferential Analysis (HIA) and Other Emerging Concepts: In Understanding Mitochondrial Variation In Pathogenesis: There is no More Low-Hanging Fruit
Vila-Sanjurjo, Antón; Smith, Paul M.; Elson, Joanna L. (Springer Nature, 2021)[Abstract] Here we summarize our latest efforts to elucidate the role of mtDNA variants affecting the mitochondrial translation machinery, namely variants mapping to the mt-rRNA and mt-tRNA genes. Evidence is accumulating ... -
Minority Gene Expression Profiling: Probing the Genetic Signatures of Pathogenesis Using Ribosome Profiling
Vila-Sanjurjo, Antón; Juárez, Diana; Loyola, Steev; Torres, Michael; Leguia, Mariana (Oxford Academic, 2020-03-27)[Abstract] Minority Gene Expression Profiling (MGEP) refers to a scenario where the expression profiles of specific genes of interest are concentrated in a small cellular pool that is embedded within a larger, non-expressive ... -
Mitochondrial DNA Mutations Induce Mitochondrial Biogenesis and Increase the Tumorigenic Potential of Hodgkin and Reed–Sternberg Cells
Haumann, Sophie; Boix, Julia; Knuever, Jana; Bieling, Angela; Vila-Sanjurjo, Antón; Elson, Joanna L.; Blakely, Emma L.; Taylor, Robert W.; Riet, Nicole; Abken, Hinrich; Kashkar, Hamid; Hornig-Do, Hue-Tran; Wiesner, Rudolf (Oxford University Press, 2020-04-06)[Abstract] Functioning mitochondria are crucial for cancer metabolism, but aerobic glycolysis is still considered to be an important pathway for energy production in many tumor cells. Here we show that two well established, ... -
Mycena Fragosa (Mycenaceae), a New Species From the Fragas in Northwestern Spain
Villarreal, M.; Traba, José María; Couceiro, A.; Naveira, Horacio; Vila-Sanjurjo, Antón (Sociedad Ibérica de Micología, 2023-11-28)[Resumen] Una nueva especie de Mycena del noroeste de España es descrita, ilustrada y comparada con especies afines. Esta especie pertenece a M. sect. Viscipelles y se caracteriza morfológicamente por tener un tamaño ... -
Our Current Understanding of the Toxicity of Altered Mito-Ribosomal Fidelity During Mitochondrial Protein Synthesis: What Can It Tell Us About Human Disease?
Vila-Sanjurjo, Antón; Mallo, Natalia; Atkins, J. F.; Elson, Joanna L.; Smith, Paul M. (Frontiers, 2023-06-30)[Abstract] Altered mito-ribosomal fidelity is an important and insufficiently understood causative agent of mitochondrial dysfunction. Its pathogenic effects are particularly well-known in the case of mitochondrially induced ... -
Outer Membrane Protein FrpA, the Siderophore Piscibactin Receptor of Photobacterium damselae subsp. piscicida, as a Subunit Vaccine Against Photobacteriosis in Sole (Solea senegalensis)
Valderrama Pereira, Andrea Katherine; Balado, Miguel; Rey-Varela, Diego; Rodríguez, Jaime; Vila-Sanjurjo, Antón; Jiménez, Carlos; Lemos, Manuel L. (Elsevier, 2019-09-30)[Abstract] Photobacteriosis caused by Photobacterium damselae subsp. piscicida (Pdp) remains one of the main infectious diseases affecting cultured fish in Mediterranean countries. Diverse vaccine formulations based in the ... -
Precision Medicine and Precision Public Health in the Era of Pathogen Next-Generation Sequencing
Leguia, Mariana; Vila-Sanjurjo, Antón; Chain, Patrick; Maljkovic Berry, Irina; Jarman, Richard G.; Pollett, Simon (Oxford Academic, 2019-11-21)[Abstract] This brief report serves as an introduction to a supplement of the Journal of Infectious Diseases entitled “Next-Generation Sequencing (NGS) Technologies to Advance Global Infectious Disease Research.” We briefly ... -
Structural Analysis of Mitochondrial rRNA Gene Variants Identified in Patients With Deafness
Vila-Sanjurjo, Antón; Mallo, Natalia; Elson, Joanna L.; Smith, Paul M.; Blakely, Emma L.; Taylor, Robert W. (Frontiers, 2023-06-08)[Abstract] The last few years have witnessed dramatic advances in our understanding of the structure and function of the mammalian mito-ribosome. At the same time, the first attempts to elucidate the effects of mito-ribosomal ...
