Listar por autor "Varela Vázquez, Adrián"
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Extracellular Vesicles Enriched in Connexin 43 Promote a Senescent Phenotype in Bone and Synovial Cells Contributing to Osteoarthritis Progression
Varela-Eirín, Marta; Carpintero-Fernández, Paula; Guitián-Caamaño, Amanda; Varela Vázquez, Adrián; García-Yuste, Alejandro; Sánchez Temprano, Agustín; Bravo López, Susana Belén; Yáñez-Cabanas, José; Fonseca, Eduardo; Largo, R.; Mobasheri, Ali; Caeiro, José Ramón; Mayán, María D. (Springer Nature, 2022)[Abstract] The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that high ... -
Role of Connexin43 in Tumour Prograssion and Drug Resistance in BRAF-driven Tumors
Varela Vázquez, Adrián (2021)[Abstract] Mutations in the oncogenic serine/threonine protein kinase BRAF are casually involved in the onset and progression of several cancers, including more than 50% of cases of melanoma. Malignant melanoma is the ... -
Senolytic Activity of Small Molecular Polyphenols from Olive Restores Chondrocyte Redifferentiation and Promotes a Pro-Regenerative Environment in Osteoarthritis
Varela-Eirín, Marta; Carpintero-Fernández, Paula; Sánchez Temprano, Agustín; Varela Vázquez, Adrián; Luis Paíno, Carlos; Casado-Díaz, Antonio; Calañas Continente, Alfonso; Mato-Abad, Virginia; Fonseca, Eduardo; Kandouz, Mustapha; Blanco, Alfonso; Caeiro, José Ramón; Mayan, Maria D. (Impact Journals LLC, 2020-08-03)[Abstract] Articular cartilage and synovial tissue from patients with osteoarthritis (OA) show an overactivity of connexin43 (Cx43) and accumulation of senescent cells associated with disrupted tissue regeneration and ... -
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
Varela-Eirín, Marta; Varela Vázquez, Adrián; Guitián-Caamaño, Amanda; Luis Paíno, Carlos; Mato-Abad, Virginia; Largo, Raquel; Aasen, Trond; Tabernero, Arantxa; Fonseca, Eduardo; Kandouz, Mustapha; Caeiro, José Ramón; Blanco, Alfonso; Mayan, Maria D. (Nature Publishing Group, 2018-12-05)[Abstract] Osteoarthritis (OA), a chronic disease characterized by articular cartilage degeneration, is a leading cause of disability and pain worldwide. In OA, chondrocytes in cartilage undergo phenotypic changes and ...